Table of Contents
Chemistry, Volume 2, Issue 1 (March 2020) – 12 articles
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Cover Story (view full-size image) A hollow cubic coordination cage catalyses the aldol condensation of indane-1,3-dione to the [...] Read more. A hollow cubic coordination cage catalyses the aldol condensation of indane-1,3-dione to the product bindone. We know that neutral organic guest molecules can bind inside the cage cavity in water driven by the hydrophobic effect, and that anions accumulate around the exterior surface of the highly cationic (16+) cage driven by ion-pairing effects. Thus, the cage works by bringing both neutral indane-1,3-dione and its enolate anion (pKa 7) into close contact, in water, using orthogonal interactions. This co-location of electrophile and nucleophile results in catalysed aldol condensation, and highlights a general and possible mechanism for catalysed reactions between neutral/hydrophobic and anionic reaction partners. View this paper.