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Open AccessArticle

Selective Proton-Mediated Transport by Electrogenic K+-Binding Macrocycles

1
Lehn Institute of Functional Materials, School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China
2
Adaptive Supramolecular Nanosystems Group, Institut Européen des Membranes, University of Montpellier ENSCM-UM-CNRS UMR-5635, Place E. Bataillon, CC 047, F-34095 Montpellier, France
*
Author to whom correspondence should be addressed.
Chemistry 2020, 2(1), 11-21; https://doi.org/10.3390/chemistry2010003
Received: 13 December 2019 / Revised: 16 January 2020 / Accepted: 16 January 2020 / Published: 20 January 2020
(This article belongs to the Special Issue Supramolecular Chemistry in the 3rd Millennium)
Synthetic K+-binding macrocycles have potential as therapeutic agents for diseases associated with KcsA K+ channel dysfunction. We recently discovered that artificial self-assembled n-alkyl-benzoureido-15-crown-5-ether form selective ion-channels for K+ cations, which are highly preferred to Na+ cations. Here, we describe an impressive selective activation of the K+ transport via electrogenic macrocycles, stimulated by the addition of the carbonyl cyanide-4-(trifluoromethoxy) phenylhydrazone (FCCP) proton carrier. The transport performances show that both the position of branching or the size of appended alkyl arms favor high transport activity and selectivity SK+/Na+ up to 48.8, one of the best values reported up to now. Our study demonstrates that high K+/Na+ selectivity obtained with natural KcsA K+ channels is achievable using simpler artificial macrocycles displaying constitutional functions. View Full-Text
Keywords: ion-channels; crown-ethers; bilayer membranes; self-assembly; supramolecular chemistry ion-channels; crown-ethers; bilayer membranes; self-assembly; supramolecular chemistry
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Li, Y.-H.; Zheng, S.-P.; Wang, D.; Barboiu, M. Selective Proton-Mediated Transport by Electrogenic K+-Binding Macrocycles. Chemistry 2020, 2, 11-21.

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