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Nonceliac Gluten Sensitivity—A Masquerading IBS or a Real Phenomenon?

Department of Pediatrics, Gastroenterology Division, Marshall University School of Medicine, Huntington, WV 25701, USA
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Author to whom correspondence should be addressed.
Gastrointest. Disord. 2020, 2(2), 118-122; https://doi.org/10.3390/gidisord2020011
Received: 5 April 2020 / Revised: 15 April 2020 / Accepted: 28 April 2020 / Published: 2 May 2020
(This article belongs to the Special Issue Coeliac Disease)
The gluten-free diet has become popular among the public. People who are using this diet have reported symptom relief once gluten has been removed from their diet. Nonceliac gluten sensitivity (NCGS) has emerged as a new diagnosis for those patients who have tested negative for celiac disease. Although there are no diagnostic markers established for NCGS, its symptomatology ranges from gastrointestinal symptoms to neuropsychiatric symptoms. Indeed, some of these symptoms are also seen in patients with irritable bowel syndrome (IBS), such as abdominal pain, bloating, altered bowel movement, diarrhea, and constipation. It is important to add that unlike celiac disease, NGCS has never been associated with any long-term malignancy. We aim to review the recent clinical data available on this topic and address the overlap symptoms between NCGS and IBS. We concluded that despite the overlap symptoms between both diseases, NCGS is a real clinical phenomenon that awaits its own diagnostic clinical criteria and specific laboratory markers. We suggest that patients with gluten sensitivity who are negative for celiac disease should be considered for NCGS. View Full-Text
Keywords: gluten; NCGS; IBS; celiac disease gluten; NCGS; IBS; celiac disease
MDPI and ACS Style

Elitsur, Y.; Preston, D. Nonceliac Gluten Sensitivity—A Masquerading IBS or a Real Phenomenon? Gastrointest. Disord. 2020, 2, 118-122.

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