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Correlation between Helicobacter pylori Infection and Gastric Atrophy Examined in the Sera of Mongolian People

1
Department of Microbiology and Immunology, School of Pharmacy and Bio-Medicine Mongolian National University of Medical Sciences, 14210 Ulaanbaatar, Mongolia
2
Department of Nutritional Science, Faculty of Human Life Science, Shokei University, 861-8538 Kumamoto, Japan
3
Department of Internal Medicine, Division of Gastroenterology, Jichi Medical University, 329-0498 Shimotsuke-shi, Tochigi-ken, Japan
4
National Center for Communicable Disease, 13335 Ulaanbaatar, Mongolia
5
Department of Infection and Immunity, Division of Virology, Jichi Medical University, Jichi Medical University, 329-0498 Shimotsuke-shi, Tochigi-ken, Japan
6
Tamano Institute of Health and Human Services, 706-0002 Okayama, Japan
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Gastrointest. Disord. 2019, 1(2), 241-252; https://doi.org/10.3390/gidisord1020019
Received: 11 December 2018 / Revised: 12 March 2019 / Accepted: 21 March 2019 / Published: 3 April 2019
(This article belongs to the Special Issue Biomarkers in Gastric Diseases)
Serum specimens obtained from 680 individuals were examined to measure the amounts of pepsinogens 1 and 2, anti-CagA antibodies, and anti-Helicobacter pylori antibodies. We examined sera obtained from 610 Mongolian individuals living in the capital city, Ulaanbaatar. Seventy serum specimens were collected from Japanese people who were health-screened: These were stored at the gastroenterology laboratory of Jichi Medical University. The sera of the Japanese people were used as a control specimen. Two enzyme-linked immunosorbent assay (ELISA) kits, an E-plate ELISA kit from Eiken Chemical Co., Ltd. (Tokyo, Japan), and a Biohit ELISA kit from Biohit Oyj (Helsinki, Finland), were used for the detection of anti-H. pylori IgG antibodies in the sera of the 610 Mongolian people. An ELISA kit EIA-4138 from DRG Instruments GmbH (Germany) was used for the detection of anti-CagA IgG antibodies in the serum specimens. Serum pepsinogens were detected by an ELISA kit from Biohit Oyj. Of the 610 serum specimens, 385 specimens tested positive for the detection of anti-H. pylori antibodies using the two ELISA kits, and 47 tested negative. For the detection of anti-H. pylori antibodies by the Biohit ELISA kit, 560 and 50 specimens were positive and negative, respectively. The ratio of serum pepsinogen 1/2 was statistically lower (p < 0.0001) in the H. pylori-positive (560 specimens) than in the H. pylori-negative (50 specimens) specimens. However, the levels of serum pepsinogen 1 had no statistical significance (p = 0.465) between the specimens of the H. pylori-positive and -negative specimens. The ratio of serum pepsinogen 1/2 was 6.74 ± 0.12 in the H. pylori-positive specimens, whereas the ratio of serum pepsinogen 1/2 was 12.69 ± 1.02 in the H. pylori-negative specimens. This study demonstrated the high prevalence of H. pylori infection in Mongolian people, including young generations, and the people infected with H. pylori possessed low pepsinogen 1/2 ratios, indicating atrophic gastritis. The serological examinations by the two ELISA kits did not consistently reflect the prevalence of H. pylori infection in Mongolian people. View Full-Text
Keywords: H. pylori; pepsinogen; pepsinogen ratio H. pylori; pepsinogen; pepsinogen ratio
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Amgalanbaatar, A.; Shimomura, H.; Sugano, K.; Bira, T.-O.; Okamoto, H.; Hirai, Y. Correlation between Helicobacter pylori Infection and Gastric Atrophy Examined in the Sera of Mongolian People. Gastrointest. Disord. 2019, 1, 241-252.

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