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Gastrointestinal Disorders
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Review

The Role of Vitamin D in the Pathogenesis of Inflammatory Bowel Disease

by
Stefano Nobile
1,*,
Michela A. Tenace
1 and
Helen M. Pappa
2
1
Department of Mother and Child Health, Salesi Children’s Hospital, via F. Corridoni 11, 60123 Ancona, Italy
2
Division of Pediatric Gastroenterology and Hepatology, SSM Health Cardinal Glennon Children’s Hospital, Saint Louis University, St. Louis, MO 63104, USA
*
Author to whom correspondence should be addressed.
Gastrointest. Disord. 2019, 1(1), 231-240; https://doi.org/10.3390/gidisord1010018
Submission received: 10 February 2019 / Revised: 26 February 2019 / Accepted: 28 February 2019 / Published: 5 March 2019
(This article belongs to the Special Issue The Interplay between Genetic Risk Factors, the Intestinal Microbiota, the Environment and Immune Responses in the Pathogenesis of IBD)
Review Reports Versions Notes

Abstract

Vitamin D has a complex role in the pathogenesis of inflammatory bowel disease (IBD), which is still under investigation. We conducted a literature search using PubMed through December 2018 through the use of relevant search terms. We found an abundance of evidence to support the role of vitamin D in regulating the innate and adaptive arms of the immune system. The pathogenesis of IBD implicates the immune dysregulation of these immune system components. Proof of concept of the vitamin’s role in the pathogenesis of IBD is the mapping of the vitamin D receptor in a region of chromosome 12, where IBD is also mapped, and specific VDR polymorphisms’ link to IBD phenotypes. Further research is needed to better delineate vitamin D’s role in preventing IBD and its potential as a therapeutic target for this disease.
Keywords: vitamin D; inflammatory bowel disease; pathogenesis; immune system vitamin D; inflammatory bowel disease; pathogenesis; immune system

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MDPI and ACS Style

Nobile, S.; Tenace, M.A.; Pappa, H.M. The Role of Vitamin D in the Pathogenesis of Inflammatory Bowel Disease. Gastrointest. Disord. 2019, 1, 231-240. https://doi.org/10.3390/gidisord1010018

AMA Style

Nobile S, Tenace MA, Pappa HM. The Role of Vitamin D in the Pathogenesis of Inflammatory Bowel Disease. Gastrointestinal Disorders. 2019; 1(1):231-240. https://doi.org/10.3390/gidisord1010018

Chicago/Turabian Style

Nobile, Stefano, Michela A. Tenace, and Helen M. Pappa. 2019. "The Role of Vitamin D in the Pathogenesis of Inflammatory Bowel Disease" Gastrointestinal Disorders 1, no. 1: 231-240. https://doi.org/10.3390/gidisord1010018

APA Style

Nobile, S., Tenace, M. A., & Pappa, H. M. (2019). The Role of Vitamin D in the Pathogenesis of Inflammatory Bowel Disease. Gastrointestinal Disorders, 1(1), 231-240. https://doi.org/10.3390/gidisord1010018

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