Emerging Trends in Obstructive Sleep Apnea
A special issue of Clocks & Sleep (ISSN 2624-5175). This special issue belongs to the section "Disorders".
Deadline for manuscript submissions: 30 November 2026 | Viewed by 4549
Special Issue Editor
Special Issue Information
Dear Colleagues,
This Special Issue, entitled “Emerging Trends in Obstructive Sleep Apnea”, highlights advances in disease characterization, novel therapies, and precision medicine approaches, which seek to inform future research directions and improve clinical outcomes for individuals affected by OSA.
Obstructive sleep apnea (OSA) is a heterogeneous disorder with distinct pathophysiological endotypes influencing treatment response. In this Special Issue, we explore the evolving understanding of these endotypes and their implications for personalized therapy. We review the predictive value of EEG-derived biomarkers on the incidence of cardiovascular disease. Notwithstanding the recognition of diverse contributors to OSA pathogenesis, the introduction of incretin agonists has emerged as a promising avenue, potentially modifying both weight-related and neuromuscular contributors to airway collapse.
Beyond airway obstruction, OSA frequently coexists with insomnia, complicating clinical management and exacerbating daytime impairment. Addressing this dual presentation requires tailored interventions that balance cognitive behavioral strategies with pharmacologic approaches. Moreover, cardiovascular complications remain a major concern, with emerging biomarkers offering novel insights into risk stratification and mechanistic pathways linking OSA to adverse outcomes.
Given the limitations of continuous positive airway pressure (CPAP) adherence, pharmacotherapy is gaining attention as a potential adjunct or alternative treatment. We investigate the latest pharmacologic developments, including agents targeting ventilatory control instability, upper airway collapsibility, and neurochemical modulation.
I would like to thank the authors who contributed to this Special Issue for their in-depth analysis and valuable insights that enhance our understanding of obstructive sleep apnea and its evolving management strategies.
Prof. Dr. Ali Albert el-Solh
Guest Editor
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Keywords
- sleep apnea
- pharmacotherapy
- GLP-1
- COMISA
- biomarkers
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