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Article

Release Profiles of Dyes and Proteins from Calcium Phosphate Microspheres with Different Crystalline Phases

Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology, Kitakyushu 808-0196, Japan
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Academic Editor: Gilbert Fantozzi
Ceramics 2021, 4(2), 291-301; https://doi.org/10.3390/ceramics4020023
Received: 28 April 2021 / Revised: 20 May 2021 / Accepted: 4 June 2021 / Published: 6 June 2021
(This article belongs to the Special Issue Advances in Ceramics)
Calcium phosphate is attracting attention as a bone repair material and a controlled-release carrier of various drugs such as bone disease therapeutic agents and anticancer agents. Compared with some bioabsorbable polymers, calcium phosphates have the advantage of preventing a pH decrease in the surrounding body fluid. However, there are few studies comparing the effect of supporting substances with different physicochemical properties on the production of calcium phosphate microspheres with different crystalline phases. In this study, we investigated conditions for obtaining low crystallinity apatite and octacalcium phosphate (OCP) microspheres from calcium carbonate microspheres with different crystalline structures using a simple phosphoric acid treatment. Furthermore, we investigated the adsorption and release behavior of different dyes and proteins from the apatite and OCP microspheres. Overall, the factors governing the adsorption and release behavior are different depending on the molecular size and surface charge of the dye and protein adsorbates. View Full-Text
Keywords: apatite; octacalcium phosphate (OCP); microsphere; drug delivery; dye; protein; mesopore; surface charge apatite; octacalcium phosphate (OCP); microsphere; drug delivery; dye; protein; mesopore; surface charge
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MDPI and ACS Style

Miyazaki, T.; Masuda, K.; Sakamoto, K. Release Profiles of Dyes and Proteins from Calcium Phosphate Microspheres with Different Crystalline Phases. Ceramics 2021, 4, 291-301. https://doi.org/10.3390/ceramics4020023

AMA Style

Miyazaki T, Masuda K, Sakamoto K. Release Profiles of Dyes and Proteins from Calcium Phosphate Microspheres with Different Crystalline Phases. Ceramics. 2021; 4(2):291-301. https://doi.org/10.3390/ceramics4020023

Chicago/Turabian Style

Miyazaki, Toshiki, Koudai Masuda, and Kazuki Sakamoto. 2021. "Release Profiles of Dyes and Proteins from Calcium Phosphate Microspheres with Different Crystalline Phases" Ceramics 4, no. 2: 291-301. https://doi.org/10.3390/ceramics4020023

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