Abstract
Peptides derived from food proteins exhibit a variety of bioactivities, such as the inhibition of angiotensin converting enzyme (ACE; EC 3.4.15.1), dipeptidyl peptidase IV (DPP4; EC 3.4.14.5), α-glucosidase (EC 3.2.1.20), α-amylase (EC 3.2.1.1), etc., as well as antioxidative, immunomodulating, and antithrombotic functions, etc. The above-mentioned inhibitory functions of peptides are related to the regulation of blood pressure level (ACE inhibitors) and blood glucose concentration (DPP IV, α-glucosidase, α-amylase inhibitors). Thus, bioactive peptides are considered as food components that play an important role in the prevention of, e.g., hypertension, type 2 diabetes, and/or metabolic syndrome. Progress in the development of computer technologies has contributed to the elaboration of tools that are useful in the theoretical prediction of the properties of food components. Such methodologies are called in silico analyses and have become one of the three approaches applied in the study of proteins and peptides. In silico analyses are less costly and time-consuming when compared to classical approaches relying on the involvement of laboratory procedures to produce peptides from food. Thus, the aim of this study is to present the options available in the BIOPEP-UWM® database of proteins and bioactive peptide sequences that can be useful in the evaluation of proteins as sources of bioactive peptides. Such options can be exemplified on any protein sequence available in the BIOPEP-UWM database. They include the elaboration of the profile of the potential biological activity of a protein, the frequency of the occurrence of peptides with a given activity within a protein, and the prediction of the enzymatic release of biopeptides from a protein using qualitative and quantitative criteria. Moreover, the search options of this database, as well as new updates, will be presented.
Author Contributions
Conceptualization, A.I.; methodology, A.I.; software, A.I., M.D. and P.M.; validation, A.I., M.D. and P.M.; formal analysis, A.I., M.D. and P.M.; investigation, A.I., M.D. and P.M.; resources, A.I., M.D. and P.M.; data curation, A.I., M.D. and P.M.; writing—original draft preparation, A.I.; writing—review and editing, A.I.; visualization, A.I.; supervision, A.I.; project administration, A.I., M.D. and P.M.; funding acquisition, M.D. All authors have read and agreed to the published version of the manuscript.
Funding
This research was funded by the Minister of Education and Science in the range of the program entitled “Regional Initiative of Excellence” for the years 2019–2023, Project No. 010/RID/2018/19, with a received amount of funding 12,000,000, and a University of Warmia and Mazury, grant number 17.610-014-110.
Institutional Review Board Statement
Not applicable.
Informed Consent Statement
Not applicable.
Data Availability Statement
BIOPEP-UWM database is available at https://biochemia.uwm.edu.pl/biopep-uwm/ (accessed on 13 November 2023).
Conflicts of Interest
The authors declare no conflict of interest.
Disclaimer/Publisher’s Note: The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content. |
© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).