Abstract
Background and Objectives: There is a high inter-individual variability in the postprandial response to an oral glucose tolerance test (OGTT). However, there is limited evidence on whether the individual postprandial response is associated with the success of a weight management intervention. This work examines postprandial glucose and insulin response to an OGTT as predictors for changes in anthropometric parameters after a standardized weight loss intervention. Methods: Adults (18–65 years) with a body mass index (BMI) between 30.0 and 39.9 kg/m2 were recruited for the Lifestyle Intervention (LION) study (NCT04023942). Blood samples were taken before the start of the 8-week formula diet and during an OGTT. Several parameters describing the postprandial glucose and insulin response (e.g., area under the curve, peak time, and concentration) were calculated. Anthropometric parameters (e.g., body weight, fat mass) were collected before and after the 8-week formula diet. Finally, regression analyses adjusted for age and sex were fitted. Results: A total of 272 participants (mean age 45 ± 11 years, BMI 34.5 ± 2.9 kg/m2, 64% women) were included in the analysis. The formula diet resulted in an average weight loss of 11.8 ± 3.5 kg body weight and 8.2 ± 2.5 kg (4.1 ± 2.2%) fat mass. Postprandial parameters describing the glucose or insulin response from a total of 161 OGTTs showed no significant associations with changes in anthropometric parameters. Discussion: The examined postprandial glucose or insulin responses are not associated with weight loss success after an 8-week formula diet.
Author Contributions
Conceptualization, A.R., G.S. and C.H.; methodology, A.R. and C.H.; formal analysis, A.R. and G.S.; investigation, A.R., G.S., H.H. and C.H.; data curation, A.R.; writing—original draft preparation, A.R.; writing—review and editing, A.R., G.S., M.W., H.H. and C.H.; visualization, A.R. and G.S.; supervision, C.H.; project administration, A.R., M.W.; funding acquisition, C.H. All authors have read and agreed to the published version of the manuscript.
Funding
The study was funded by the German Federal Ministry of Education and Research (reference number: 01EA1709).
Institutional Review Board Statement
The study was conducted in accordance with the Declaration of Helsinki, and approved by the Ethics Committee of the School of Medicine and Health, Technical University of Munich (vote 69/19S).
Informed Consent Statement
Informed consent was obtained from all subjects involved in the study.
Data Availability Statement
The data presented in this study are available on request from the corresponding author.
Conflicts of Interest
H.H. is a member of the scientific advisory board of Oviva AG (Zurich, Switzerland) and C.H. of 4sigma GmbH (Oberhaching, Germany). H.H. and C.H. received speaker honoraries from Novo Nor (Copenhagen, Denmark).
Disclaimer/Publisher’s Note: The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content. |
© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).