Next Article in Journal
Maternal Dietary Intervention during Lactation Impacts the Maternal Faecal and Human Milk Microbiota
Previous Article in Journal
Local Retail Food Environment Exposure and Diet Quality in Rural and Urban Adults: A Longitudinal Analysis of the ORISCAV-LUX Study
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Proceedings
Volume 91
Issue 1
10.3390/proceedings2023091123
proceedings-logo
Submit to this Journal
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles thumb_up
...
Endorse textsms
...
Comment
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Abstract

The Impact of Inorganic Nitrate-Rich Beetroot Juice on Microvascular Blood Flow, Cognitive Function, and Other Hemodynamic Outcomes in Postmenopausal Women †

by
Begum Celik
1,*,
Jeremy Spencer
1,
Daniel Lamport
2,
Noa Argomaniz
3 and
Charlotte Mills
1
1
Hugh Sinclair Unit of Human Nutrition, School of Chemistry, Food and Nutritional Sciences, University of Reading, Reading RG6 6AP, UK
2
Department of Psychology, School of Psychology and Clinical Language Sciences, University of Reading, Reading RG6 6AL, UK
3
Department of Nutritional Sciences, School of Life Course and Population Sciences, Faculty of Life Science and Medicine, King’s College London, London WC2R 2LS, UK
*
Author to whom correspondence should be addressed.
†
Presented at the 14th European Nutrition Conference FENS 2023, Belgrade, Serbia, 14–17 November 2023.
Proceedings 2023, 91(1), 123; https://doi.org/10.3390/proceedings2023091123
Published: 17 January 2024
(This article belongs to the Proceedings of The 14th European Nutrition Conference FENS 2023)
Versions Notes

Abstract

:
Background: Inorganic nitrate found in beetroot and green leafy vegetables has been demonstrated to reduce cardiovascular disease risk factors, including reducing blood pressure (BP) and the stiffness of blood vessels by increasing levels of nitric oxide (NO). The most beneficial effects of inorganic nitrate have been observed in young, healthy populations, whereas its impact on at-risk populations, such as postmenopausal women, is currently unknown. Objective: the primary aim of the trial is to evaluate the effectiveness of nitrate-rich beetroot juice in enhancing microvascular blood flow and cognitive function in postmenopausal women. Methods: We conducted a double-blind, three-armed, randomised, and controlled crossover trial with 24 postmenopausal women (aged 45 or older and having not had a period for over one year). The interventions were beetroot juice (BJ), nitrate-depleted BJ (NDJB), or NDBJ supplemented with potassium nitrate (0.4 g) to concurrently test if betalains, as well as nitrate, play a role in the vascular and cognitive effects. Cognitive tasks (episodic memory: Rey auditory verbal learning test; executive function: Stroop task, digit span backward and forward) and microvascular function (Laser Doppler Imaging (LDI) with iontophoresis; endothelium-independent and -dependent) were measured in participants before and 2.5 h after ingestion of the intervention. In addition, BP was measured in triplicate every 15 min from the baseline for 2.5 h. Results: The baseline characteristics of the participants recruited to date are as follows (mean and standard deviation)—age (years): 60 ± 5, BMI (kg/ m2): 23.8 ± 3.1, systolic BP (mmHg): 120 ± 14, and diastolic BP (mmHg): 75 ± 8. Early results indicated no significant difference between the groups with respect to SBP or DBP. A statistical analysis of the full data set, including endothelium-dependent and -independent microvascular function and cognitive tests, will be presented. Discussion: the results of this trial will help shed further light on the impact of dietary nitrate and the phytochemicals present in beetroot on human vascular and cognitive function.

Author Contributions

The study was designed by B.C., C.M. and J.S., B.C. conducted the research, analysed the data, and wrote the manuscript. N.A. contributed to the conduct of the research. D.L. provided advice for cognitive test design and statistical analysis. All authors read, modified, and approved the final manuscript. All authors have read and agreed to the published version of the manuscript.

Funding

This study was funded by the Ministry of National Education of Türkiye.

Institutional Review Board Statement

The study was conducted in accordance with the Declaration of Helsinki, and approved by the School of Chemistry, Food, and Pharmacy Research Ethics Committee (REC 05/2023).

Informed Consent Statement

Informed consent was obtained from all subjects involved in the study.

Data Availability Statement

Data sharing not applicable.

Conflicts of Interest

The authors declare no conflict of interest.
Disclaimer/Publisher’s Note: The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content.

Share and Cite

MDPI and ACS Style

Celik, B.; Spencer, J.; Lamport, D.; Argomaniz, N.; Mills, C. The Impact of Inorganic Nitrate-Rich Beetroot Juice on Microvascular Blood Flow, Cognitive Function, and Other Hemodynamic Outcomes in Postmenopausal Women. Proceedings 2023, 91, 123. https://doi.org/10.3390/proceedings2023091123

AMA Style

Celik B, Spencer J, Lamport D, Argomaniz N, Mills C. The Impact of Inorganic Nitrate-Rich Beetroot Juice on Microvascular Blood Flow, Cognitive Function, and Other Hemodynamic Outcomes in Postmenopausal Women. Proceedings. 2023; 91(1):123. https://doi.org/10.3390/proceedings2023091123

Chicago/Turabian Style

Celik, Begum, Jeremy Spencer, Daniel Lamport, Noa Argomaniz, and Charlotte Mills. 2023. "The Impact of Inorganic Nitrate-Rich Beetroot Juice on Microvascular Blood Flow, Cognitive Function, and Other Hemodynamic Outcomes in Postmenopausal Women" Proceedings 91, no. 1: 123. https://doi.org/10.3390/proceedings2023091123

APA Style

Celik, B., Spencer, J., Lamport, D., Argomaniz, N., & Mills, C. (2023). The Impact of Inorganic Nitrate-Rich Beetroot Juice on Microvascular Blood Flow, Cognitive Function, and Other Hemodynamic Outcomes in Postmenopausal Women. Proceedings, 91(1), 123. https://doi.org/10.3390/proceedings2023091123

Article Metrics

Back to TopTop