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Open AccessAbstract

Validation of a Screening Method Based on a Needle Stochastic Sensor for the Determination of Interleukins 1β, 6, and 12 in Biological Samples

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Faculty of Applied Chemistry and Material Science, University Politehnica of Bucharest, Bucharest 060021, Romania
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Laboratory of Electrochemistry and PATLAB, National Institute of Research for Electrochemistry and Condensed Matter, Bucharest 060021, Romania
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Author to whom correspondence should be addressed.
Presented at the Virtual Eurachem Workshop 2020—“Quality Assurance for Analytical Laboratories in the University Curriculum”, 14–15 July 2020; Available online: https://eurachem2020.ro/.
Proceedings 2020, 55(1), 14; https://doi.org/10.3390/proceedings2020055014
Published: 10 October 2020
Interleukins proved to be valuable biomarkers for different diseases. Interleukins 1β, 6, and 12 can be used as biomarkers for brain cancer diagnosis, and therefore this paper proposed a needle stochastic sensor based on protoporphyrin IX immobilized in nano-diamond paste for fast screening of biological samples, such as whole blood, urine and brain tumoral tissue, for these interleukins. The results obtained using this needle stochastic sensor proved that the interleukins 1β, 6, and 12 can be reliably determined from whole blood, urine and brain tumoral tissue, with recoveries higher than 96.00% and with relative standard deviations lower than 1.00%. The validation of the method was performed using whole blood and tissue samples collected from the patients confirmed with brain tumor.
Keywords: interleukins; stochastic sensors; method validation interleukins; stochastic sensors; method validation
MDPI and ACS Style

Gheorghe, S.S.; Ilie-Mihai, R.M.; Stefan-van Staden, R.-I.; Bratei, A. Validation of a Screening Method Based on a Needle Stochastic Sensor for the Determination of Interleukins 1β, 6, and 12 in Biological Samples. Proceedings 2020, 55, 14.

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