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Mechanisms of Inhibitory Effects of Polysubstituted Pyrimidines on Prostaglandin E2 Production

1
Institute of Experimental Medicine, The Czech Academy of Sciences, 142 20 Prague, Czech Republic
2
Institute of Organic Chemistry and Biochemistry, The Czech Academy of Sciences, 166 10 Prague, Czech Republic
*
Author to whom correspondence should be addressed.
Presented at the 2nd Molecules Medicinal Chemistry Symposium (MMCS): Facing Novel Challenges in Drug Discovery, Barcelona, Spain, 15–17 May 2019.
Proceedings 2019, 22(1), 24; https://doi.org/10.3390/proceedings2019022024
Published: 7 August 2019
(This article belongs to the Proceedings of The Molecules Medicinal Chemistry Symposium)
PDF [187 KB, uploaded 7 August 2019]
Note: In lieu of an abstract, this is an excerpt from the first page.

Excerpt

The pyrimidine heterocycle represents an elemental structural motif of numerous drugs. [...]
Keywords: pyrimidine analogues; prostaglandin E2; prostaglandin E2 synthase-1 inhibitors; anti-inflammatory activity pyrimidine analogues; prostaglandin E2; prostaglandin E2 synthase-1 inhibitors; anti-inflammatory activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Zídek, Z.; Kolman, V.; Baszczyňski, O.; Kalčic, F.; Board, D.; Janeba, Z. Mechanisms of Inhibitory Effects of Polysubstituted Pyrimidines on Prostaglandin E2 Production. Proceedings 2019, 22, 24.

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