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Open AccessCase Report

Dengue Virus and Influenza A Virus Co-Infection in Pregnancy: A Case Report

Magister in Biomedical Sciences, Universidad del Valle, Cali 760001, Colombia
Department of Pathology, Universidad del Valle, Cali 760001, Colombia
Department of Pathology, Universidad Industrial de Santander, Bucaramanga 680001, Colombia
Emergent Viruses and Disease - VIREM, Universidad del Valle, Cali 760001, Colombia
Author to whom correspondence should be addressed.
Trop. Med. Infect. Dis. 2019, 4(2), 84;
Received: 8 April 2019 / Revised: 25 April 2019 / Accepted: 26 April 2019 / Published: 21 May 2019
(This article belongs to the Special Issue Epidemiology of Dengue: Past, Present and Future)
Dengue is still an important cause of disease and mortality in tropical countries, as is influenza A virus, which is also a cause of epidemics all over the globe. In this article, we present the case of a 31-year-old woman who was in her second trimester of pregnancy and presented with severe dengue with hematological and neurological complications, and premature labor. She was misdiagnosed with bacterial infection and received antibiotic treatment with no improvement of the clinical manifestations and previous to death, she was diagnosed with dengue infection. She died from cardiorespiratory arrest. In the postmortem evaluation, influenza A co-infection was confirmed and characterization of the tissue damage and immune response in lung, liver, kidney, heart, spleen, and brain was determined, finding a severe inflammatory response in lung with T cells and macrophages infiltrating the tissue. This case report highlights the risks of accepting a single diagnosis, especially in endemic countries to multiple tropical diseases, which can lead to delay in appropriate treatment that could reduce morbidity and mortality. View Full-Text
Keywords: dengue; Influenza; co-infection; fatal case dengue; Influenza; co-infection; fatal case
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MDPI and ACS Style

Guzmán-Rodríguez, M.; Acosta-Ñañez, H.F.; Mantilla, J.C.; Bonelo, A. Dengue Virus and Influenza A Virus Co-Infection in Pregnancy: A Case Report. Trop. Med. Infect. Dis. 2019, 4, 84.

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