Impact of TCF4 Repeat Number on Resolution of Corneal Edema after Descemet’s Stripping Only in Fuchs Dystrophy: A Pilot Study
Abstract
:1. Introduction
2. Materials and Methods
2.1. Molecular Analysis
2.2. Statistical Analysis
- Group 1: If both TCF4 alleles ≤ 40 CTG repeats;
- Group 2: If one TCF4 allele > 40 CTG repeats;
- Group 3: If both TCF4 alleles > 40 CTG repeats.
3. Results
3.1. Baseline Characteristics
3.2. Corneal Clearance
4. Discussion
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Eye | TCF4 Repeats | Age | ECC (Superior) | CCT | Time to Clearance |
---|---|---|---|---|---|
1 | 11/27 | 56 | 2071 | 601 | 3 months |
2 | 11/11 | 60 | 1518 | 616 | 3 months |
3 | 11/62 | 71 | 2274 | 699 | 2 months |
4 | 11/69 | 64 | 2041 | 629 | 3 months |
5 | 63/73 | 69 | 2149 | 617 | 3 months |
6 | 11/80 | 73 | 1785 | 651 | Non-clearance |
7 | 17/95 | 84 | 850 | 662 | 6 months |
8 | 63/73 | 58 | 3146 | 589 | 6 months |
9 | 11/123 | 78 | Not recorded | 602 | Non-clearance |
10 | 11/97 | 52 | 2470 | 534 | 2 months |
11 | 14/110 | 39 | 2589 | 577 | Non-clearance |
Explanatory Variable | VIP (SD) for Clearance Time | VIP (SD) for Clearance vs. No Clearance |
---|---|---|
Age | 1.23 (1.32) | 0.09 (0.95) |
TCF4 | 0.83 (0.75) | 1.52 (0.12) |
ECC sup | 0.41 (1.24) | 0.23 (0.47) |
CCT | 0.26 (0.65) | 0.23 (0.48) |
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Spiteri, N.; Hirnschall, N.; van Bysterveldt, K.; Hou, A.L.; Moloney, G.; Ball, M.; Vincent, A.L. Impact of TCF4 Repeat Number on Resolution of Corneal Edema after Descemet’s Stripping Only in Fuchs Dystrophy: A Pilot Study. Vision 2021, 5, 47. https://doi.org/10.3390/vision5040047
Spiteri N, Hirnschall N, van Bysterveldt K, Hou AL, Moloney G, Ball M, Vincent AL. Impact of TCF4 Repeat Number on Resolution of Corneal Edema after Descemet’s Stripping Only in Fuchs Dystrophy: A Pilot Study. Vision. 2021; 5(4):47. https://doi.org/10.3390/vision5040047
Chicago/Turabian StyleSpiteri, Natasha, Nino Hirnschall, Katherine van Bysterveldt, Alec Lin Hou, Gregory Moloney, Matthew Ball, and Andrea L. Vincent. 2021. "Impact of TCF4 Repeat Number on Resolution of Corneal Edema after Descemet’s Stripping Only in Fuchs Dystrophy: A Pilot Study" Vision 5, no. 4: 47. https://doi.org/10.3390/vision5040047
APA StyleSpiteri, N., Hirnschall, N., van Bysterveldt, K., Hou, A. L., Moloney, G., Ball, M., & Vincent, A. L. (2021). Impact of TCF4 Repeat Number on Resolution of Corneal Edema after Descemet’s Stripping Only in Fuchs Dystrophy: A Pilot Study. Vision, 5(4), 47. https://doi.org/10.3390/vision5040047