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Tomography
Volume 6
Issue 2
10.18383/j.tom.2020.00015
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Article

Diffusion-Weighted and Dynamic Contrast-Enhanced MRI Derived Imaging Metrics for Stereotactic Body Radiotherapy of Pancreatic Ductal Adenocarcinoma: Preliminary Findings

by
Richard Kinh Do
1,
Marsha Reyngold
2,
Ramesh Paudyal
3,
Jung Hun Oh
3,
Amaresha Shridhar Konar
3,
Eve LoCastro
3,
Karyn A. Goodman
4 and
Amita Shukla-Dave
1,3,*
1
Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
2
Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
3
Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, USA
4
Tisch Cancer Institute at Mount Sinai Hospital, New York, NY, USA
*
Author to whom correspondence should be addressed.
Tomography 2020, 6(2), 261-271; https://doi.org/10.18383/j.tom.2020.00015
Submission received: 5 March 2020 / Revised: 4 April 2020 / Accepted: 11 May 2020 / Published: 1 June 2020
Versions Notes

Abstract

We aimed to assess longitudinal changes in quantitative imaging metric values obtained from diffusion-weighted (DW-) and dynamic contrast-enhanced magnetic resonance imaging (DCE)-MRI at pre-treatment (TX[0]), immediately after the first fraction of stereotactic body radiotherapy (D1-TX[1]), and 6 weeks post-TX (Post-TX[2]) in patients with pancreatic ductal adenocarcinoma. Ten enrolled patients (n = 10) underwent DW- and DCE-MRI examinations on a 3.0 T scanner. The apparent diffusion coefficient, ADC (mm2/s), was derived from DW imaging data using a monoexponential model. The tissue relaxation rate, R1t, time-course data were fitted with a shutter-speed model, which provides estimates of the volume transfer constant, Ktrans (min−1), extravascular extracellular volume fraction, ve, and mean lifetime of intracellular water protons, τi (seconds). Wilcoxon rank-sum test compared the mean values, standard deviation, skewness, kurtosis, and relative percentage (r, %) changes (Δ) in ADC, Ktrans, ve, and τi values between the magnetic resonance examinations. rADCΔ2–0 values were significantly greater than rADCΔ1-0 values (P = .009). rKtransΔ2–0 values were significantly lower than rKtrans Δ1-0 values (P = .048). rveΔ2-1 and rveΔ2-0 values were significantly different (P = .016). rτiΔ2-1 values were significantly lower than rτiΔ2-0 values (P = .008). For group comparison, the pre-TX mean and kurtosis of ADC (P = .18 and P = .14), skewness and kurtosis of Ktrans values (P = .14 for both) showed a leaning toward significant difference between patients who experienced local control (n = 2) and failed early (n = 4). DW- and DCE-MRI-derived quantitative metrics could be useful biomarkers to evaluate longitudinal changes to stereotactic body radiotherapy in patients with pancreatic ductal adenocarcinoma.
Keywords: quantitative imaging; diffusion-weighted; dynamic contrast-enhanced; shutter-speed model; pancreatic ductal adenocarcinoma; stereotactic body radiotherapy quantitative imaging; diffusion-weighted; dynamic contrast-enhanced; shutter-speed model; pancreatic ductal adenocarcinoma; stereotactic body radiotherapy

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MDPI and ACS Style

Do, R.K.; Reyngold, M.; Paudyal, R.; Oh, J.H.; Konar, A.S.; LoCastro, E.; Goodman, K.A.; Shukla-Dave, A. Diffusion-Weighted and Dynamic Contrast-Enhanced MRI Derived Imaging Metrics for Stereotactic Body Radiotherapy of Pancreatic Ductal Adenocarcinoma: Preliminary Findings. Tomography 2020, 6, 261-271. https://doi.org/10.18383/j.tom.2020.00015

AMA Style

Do RK, Reyngold M, Paudyal R, Oh JH, Konar AS, LoCastro E, Goodman KA, Shukla-Dave A. Diffusion-Weighted and Dynamic Contrast-Enhanced MRI Derived Imaging Metrics for Stereotactic Body Radiotherapy of Pancreatic Ductal Adenocarcinoma: Preliminary Findings. Tomography. 2020; 6(2):261-271. https://doi.org/10.18383/j.tom.2020.00015

Chicago/Turabian Style

Do, Richard Kinh, Marsha Reyngold, Ramesh Paudyal, Jung Hun Oh, Amaresha Shridhar Konar, Eve LoCastro, Karyn A. Goodman, and Amita Shukla-Dave. 2020. "Diffusion-Weighted and Dynamic Contrast-Enhanced MRI Derived Imaging Metrics for Stereotactic Body Radiotherapy of Pancreatic Ductal Adenocarcinoma: Preliminary Findings" Tomography 6, no. 2: 261-271. https://doi.org/10.18383/j.tom.2020.00015

APA Style

Do, R. K., Reyngold, M., Paudyal, R., Oh, J. H., Konar, A. S., LoCastro, E., Goodman, K. A., & Shukla-Dave, A. (2020). Diffusion-Weighted and Dynamic Contrast-Enhanced MRI Derived Imaging Metrics for Stereotactic Body Radiotherapy of Pancreatic Ductal Adenocarcinoma: Preliminary Findings. Tomography, 6(2), 261-271. https://doi.org/10.18383/j.tom.2020.00015

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