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Tomography
Volume 4
Issue 3
10.18383/j.tom.2018.00022
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Article

Renal Energy Metabolism Following Acute Dichloroacetate and 2,4-Dinitrophenol Administration: Assessing the Cumulative Action with Hyperpolarized [1-13C]Pyruvate MRI

by
Lotte Bonde Bertelsen
,
Per Mose Nielsen
,
Haiyun Qi
,
Christian Østergaard Mariager
,
Jakob Lindhardt
and
Christoffer Laustsen
*
MR Research Centre, Department of Clinical Medicine, Aarhus University, 8200 Aarhus N, Denmark
*
Author to whom correspondence should be addressed.
Tomography 2018, 4(3), 105-109; https://doi.org/10.18383/j.tom.2018.00022
Submission received: 4 June 2018 / Revised: 5 July 2018 / Accepted: 6 August 2018 / Published: 1 September 2018
Versions Notes

Abstract

Numerous patient groups receive >1 medication and as such represent a potential point of improvement in today's healthcare setup, as the combined or cumulative effects are difficult to monitor in an individual patient. Here we show the ability to monitor the pharmacological effect of 2 classes of medications sequentially, namely, 2,4-dinitrophenol, a mitochondrial uncoupler, and dichloroacetate, a pyruvate dehydrogenase kinase inhibitor, both targeting the oxygen-dependent energy metabolism. We show that although the 2 drugs target 2 different metabolic pathways connected ultimately to oxygen metabolism, we could distinguish the 2 in vivo by using hyperpolarized [1-13C]pyruvate magnetic resonance imaging. A statistically significantly different pyruvate dehydrogenase flux was observed by reversing the treatment order of 2,4-dinitrophenol and dichloroacetate. The significance of this study is the demonstration of the ability to monitor the metabolic cumulative effects of 2 distinct therapeutics on an in vivo organ level using hyperpolarized magnetic resonance imaging.
Keywords: MRI; hyperpolarization; DCA; 2,4-DNP; metabolism MRI; hyperpolarization; DCA; 2,4-DNP; metabolism

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MDPI and ACS Style

Bertelsen, L.B.; Nielsen, P.M.; Qi, H.; Mariager, C.Ø.; Lindhardt, J.; Laustsen, C. Renal Energy Metabolism Following Acute Dichloroacetate and 2,4-Dinitrophenol Administration: Assessing the Cumulative Action with Hyperpolarized [1-13C]Pyruvate MRI. Tomography 2018, 4, 105-109. https://doi.org/10.18383/j.tom.2018.00022

AMA Style

Bertelsen LB, Nielsen PM, Qi H, Mariager CØ, Lindhardt J, Laustsen C. Renal Energy Metabolism Following Acute Dichloroacetate and 2,4-Dinitrophenol Administration: Assessing the Cumulative Action with Hyperpolarized [1-13C]Pyruvate MRI. Tomography. 2018; 4(3):105-109. https://doi.org/10.18383/j.tom.2018.00022

Chicago/Turabian Style

Bertelsen, Lotte Bonde, Per Mose Nielsen, Haiyun Qi, Christian Østergaard Mariager, Jakob Lindhardt, and Christoffer Laustsen. 2018. "Renal Energy Metabolism Following Acute Dichloroacetate and 2,4-Dinitrophenol Administration: Assessing the Cumulative Action with Hyperpolarized [1-13C]Pyruvate MRI" Tomography 4, no. 3: 105-109. https://doi.org/10.18383/j.tom.2018.00022

APA Style

Bertelsen, L. B., Nielsen, P. M., Qi, H., Mariager, C. Ø., Lindhardt, J., & Laustsen, C. (2018). Renal Energy Metabolism Following Acute Dichloroacetate and 2,4-Dinitrophenol Administration: Assessing the Cumulative Action with Hyperpolarized [1-13C]Pyruvate MRI. Tomography, 4(3), 105-109. https://doi.org/10.18383/j.tom.2018.00022

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