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Tomography
Volume 3
Issue 2
10.18383/j.tom.2017.00106
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Tomography is published by MDPI from Volume 7 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Grapho, LLC.
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Communication

Hyperpolarized 13C Magnetic Resonance Imaging Can Detect Metabolic Changes Characteristic of Penumbra in Ischemic Stroke

by
Yafang Xu
*,
Steffen Ringgaard
,
Christian Østergaard Mariager
,
Lotte Bonde Bertelsen
,
Marie Schroeder
,
Haiyun Qi
,
Christoffer Laustsen
and
Hans Stødkilde-Jørgensen
Department of Clinical Medicine, MR Research Centre, Aarhus University, Aarhus, Denmark
*
Author to whom correspondence should be addressed.
Tomography 2017, 3(2), 67-73; https://doi.org/10.18383/j.tom.2017.00106
Submission received: 4 March 2017 / Revised: 4 April 2017 / Accepted: 8 May 2017 / Published: 1 June 2017
Versions Notes

Abstract

Magnetic resonance imaging (MRI) is increasingly the method of choice for rapid stroke assessment in patients and for guiding patient selection in clinical trials. The underlying metabolic status during stroke and following treatment is recognized as an important prognostic factor; thus, new methods are required to monitor local biochemistry following cerebral infarction, rapidly and in vivo. Hyperpolarized MRI with the tracer [1-13C]pyruvate enables rapid detection of localized [1-13C]lactate production, which has recently been shown in patients, supporting its translation to assess clinical stroke. Here we show the ability of hyperpolarized 13C MRI to detect the metabolic alterations characteristic of endothelin-1-induced ischemic stroke in rodents. In the region of penumbra, determined via T2-weighted 1H MRI, both [1-13C]pyruvate delivery and [1-13C]pyruvate cellular uptake independently increased. Furthermore, we observed a 33% increase in absolute [1-13C]lactate signal in the penumbra, and we determined that half of this increase was due to increased intracellular [1-13C]pyruvate supply and half was mediated by enhanced lactate dehydrogenase-mediated [1-13C]lactate production. Future work to characterize the kinetics of delivery, uptake, and enzymatic conversions of hyperpolarized tracers following ischemic stroke could position hyperpolarized 13C MRI as an ideal technology for rapid assessment of the penumbra during the critical time window following ischemic stroke in patients.
Keywords: MRI; hyperpolarized 13C; cerebral stroke; endothelin-1 MRI; hyperpolarized 13C; cerebral stroke; endothelin-1

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MDPI and ACS Style

Xu, Y.; Ringgaard, S.; Mariager, C.Ø.; Bertelsen, L.B.; Schroeder, M.; Qi, H.; Laustsen, C.; Stødkilde-Jørgensen, H. Hyperpolarized 13C Magnetic Resonance Imaging Can Detect Metabolic Changes Characteristic of Penumbra in Ischemic Stroke. Tomography 2017, 3, 67-73. https://doi.org/10.18383/j.tom.2017.00106

AMA Style

Xu Y, Ringgaard S, Mariager CØ, Bertelsen LB, Schroeder M, Qi H, Laustsen C, Stødkilde-Jørgensen H. Hyperpolarized 13C Magnetic Resonance Imaging Can Detect Metabolic Changes Characteristic of Penumbra in Ischemic Stroke. Tomography. 2017; 3(2):67-73. https://doi.org/10.18383/j.tom.2017.00106

Chicago/Turabian Style

Xu, Yafang, Steffen Ringgaard, Christian Østergaard Mariager, Lotte Bonde Bertelsen, Marie Schroeder, Haiyun Qi, Christoffer Laustsen, and Hans Stødkilde-Jørgensen. 2017. "Hyperpolarized 13C Magnetic Resonance Imaging Can Detect Metabolic Changes Characteristic of Penumbra in Ischemic Stroke" Tomography 3, no. 2: 67-73. https://doi.org/10.18383/j.tom.2017.00106

APA Style

Xu, Y., Ringgaard, S., Mariager, C. Ø., Bertelsen, L. B., Schroeder, M., Qi, H., Laustsen, C., & Stødkilde-Jørgensen, H. (2017). Hyperpolarized 13C Magnetic Resonance Imaging Can Detect Metabolic Changes Characteristic of Penumbra in Ischemic Stroke. Tomography, 3(2), 67-73. https://doi.org/10.18383/j.tom.2017.00106

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