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Article

Dynamic Susceptibility Contrast MRI at 7 T: Tail-Scaling Analysis and Inferences about Field Strength Dependence

by
Linda Knutsson
1,2,*,
Xiang Xu
3,4,
Freddy Ståhlberg
1,5,6,
Peter B. Barker
3,4,
Emelie Lind
1,
Pia C. Sundgren
5,
Peter C. M. van Zijl
3,4 and
Ronnie Wirestam
1
1
Department of Medical Radiation Physics, Lund University, Lund, Sweden
2
Department of Radiology (Adjunct), Johns Hopkins School of Medicine, Baltimore, MD, USA
3
Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA
4
F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA
5
Department of Diagnostic Radiology, Lund University, Lund, Sweden
6
Lund University Bioimaging Center, Lund University, Lund, Sweden
*
Author to whom correspondence should be addressed.
Tomography 2017, 3(2), 74-78; https://doi.org/10.18383/j.tom.2017.00001
Submission received: 4 March 2017 / Revised: 6 April 2017 / Accepted: 8 May 2017 / Published: 1 June 2017

Abstract

Dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) following bolus injection of gadolinium contrast agent (CA) is widely used for the estimation of brain perfusion parameters such as cerebral blood volume (CBV), cerebral blood flow (CBF), and mean transit time (MTT) for both clinical and research purposes. Although it is predicted that DSC-MRI will have superior performance at high magnetic field strengths, to the best of our knowledge, there are no reports of 7 T DSC-MRI in the literature. It is plausible that the transfer of DSC-MRI to 7 T may be accompanied by increased R2* relaxivity in tissue and a larger difference in ΔR2*-versus-concentration relationships between tissue and large vessels. If not accounted for, this will subsequently result in apparent CBV and CBF estimates that are higher than those reported previously at lower field strengths. The aims of this study were therefore to assess the feasibility of 7 T DSC-MRI and to investigate the apparent field-strength dependence of CBV and CBF estimates. In total, 8 healthy volunteers were examined using DSC-MRI at 7 T. A reduced CA dose of 0.05 mmol/kg was administered to decrease susceptibility artifacts. CBV, CBF, and MTT maps were calculated using standard DSC-MRI tracer-kinetic theory. Subject-specific arterial partial volume correction factors were obtained using a tail-scaling approach. Compared with literature values obtained using the tail-scaling approach at 1.5 T and 3 T, the CBV and CBF values of the present study were found to be further overestimated. This observation is potentially related to an inferred field-strength dependence of transverse relaxivities, although issues related to the CA dose must also be considered.
Keywords: DSC-MRI; perfusion; high field; tail scaling; 7 T DSC-MRI; perfusion; high field; tail scaling; 7 T

Share and Cite

MDPI and ACS Style

Knutsson, L.; Xu, X., 3,4; Ståhlberg, F.; Barker, P.B.; Lind, E.; Sundgren, P.C.; van Zijl, P.C.M.; Wirestam, R. Dynamic Susceptibility Contrast MRI at 7 T: Tail-Scaling Analysis and Inferences about Field Strength Dependence. Tomography 2017, 3, 74-78. https://doi.org/10.18383/j.tom.2017.00001

AMA Style

Knutsson L, Xu X 3,4, Ståhlberg F, Barker PB, Lind E, Sundgren PC, van Zijl PCM, Wirestam R. Dynamic Susceptibility Contrast MRI at 7 T: Tail-Scaling Analysis and Inferences about Field Strength Dependence. Tomography. 2017; 3(2):74-78. https://doi.org/10.18383/j.tom.2017.00001

Chicago/Turabian Style

Knutsson, Linda, Xiang Xu 3,4, Freddy Ståhlberg, Peter B. Barker, Emelie Lind, Pia C. Sundgren, Peter C. M. van Zijl, and Ronnie Wirestam. 2017. "Dynamic Susceptibility Contrast MRI at 7 T: Tail-Scaling Analysis and Inferences about Field Strength Dependence" Tomography 3, no. 2: 74-78. https://doi.org/10.18383/j.tom.2017.00001

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