Tomography, Volume 11, Issue 12 (December 2025) – 7 articles

Background/Objectives: To identify preoperative MRI features using computer-assisted diagnosis (CAD) that are associated with invasive disease-free survival (IDFS) and distant metastasis-free survival (DDFS) in patients with primarily operable triple-negative breast cancer (TNBC). Methods: This retrospective study was approved by the institutional review board with informed consent was waived. Between January 2012 and December 2014, 74 consecutive women with primary TNBC (mean age, 51 years; range, 29–77 years) who underwent preoperative MRI were included and followed until August 2021. Dynamic contrast-enhanced and T2-weighted images were obtained using 3T scanners. Peritumoral edema and central necrosis were evaluated retrospectively. CAD was used to extract 3D diameters, angiovolume, and kinetic parameters, and kinetic heterogeneity was calculated. Cox proportional hazards models were used to assess associations between MRI features and IDFS and DDFS, adjusting for clinicopathologic factors. Results: During a median follow-up of 80.9 months, 12 patients developed invasive disease, and 8 developed distant metastasis. In multivariable analysis, peak enhancement (hazard ratio [HR], 1.40; 95% confidence interval [CI], 1.06–1.84; p = 0.019) and angiovolume (HR, 2.86; 95% CI, 1.26–6.47; p = 0.012) were independently associated with IDFS, whereas angiovolume (HR, 2.47; 95% CI: 1.28–4.78; p = 0.007) was independently associated with DDFS. Conclusions: Preoperative CAD-derived MRI features, particularly peak enhancement and angiovolume, were associated with IDFS in TNBC patients whereas angiovolume alone was associated with DDFS. Full article

Introduction: Myotonic dystrophy type 1 is the most prevalent muscular dystrophy in adults, characterized by weakness, impaired functional abilities, and myotonia. However, little is known about the relationship between quantitative MRI measures (fat fraction and T₂ relaxation time) and clinical findings of the upper extremity. This study assessed forearm muscle structure in patients with myotonic dystrophy using quantitative MRI and correlated these measures with strength, function, and handgrip myotonia. Materials and Methods: Eighteen adults with myotonic dystrophy type 1 underwent MRI using three-point Dixon and T₂ spin echo imaging of the forearm. Results: The average fat fraction and T₂ relaxation time were greatest in the flexor digitorum profundus (26.7% and 55.6 ms, respectively). Correlations were found between quantitative MRI values and clinical tests of strength (r = −0.61 to −0.92, p < 0.01), function (r = −0.64 to −0.83, p < 0.01), and handgrip myotonia (r = 0.48, p < 0.05). Overall, the anterior forearm fat fraction values showed higher correlations with strength and function compared to those of the posterior forearm. Discussion: Our results support the use of quantitative MRI measures to assess forearm disease pathology and show potential to monitor the effectiveness of therapeutic treatments in patients with myotonic dystrophy type 1. Full article

Background/Objectives: To assess diagnostic accuracy of two-dimensional (2D) projection methods for rapid visual quality control of automated volumetric (3D) lung segmentations compared with slice-based 3D review of segmentation results for application in large-scale studies. Methods: Segmentation of right and left lungs on T1-weighted MRI of 300 participants of the German National Cohort (NAKO) study was performed using the nnU-NET framework. Three variants of 2D projection images of segmentation masks were created: maximum intensity projection (MIP) using pseudo-chromadepth encoding with different color spectra for right and left lung (Colored_MIP) and standard deviation projection of segmentation mask outlines, encoded in black-and-white (Gray_outline) or using color-encoding (Colored_outline). The worst of two ratings by two independent raters conducting slice-based review for segmentation errors on underlying imaging data and review for mislabeling errors served as the standard of reference. All variants were evaluated by five raters each for identification of segmentation errors and the majority rating was used as index test. The time required for review was recorded and diagnostic accuracies were calculated. Results: Sensitivities of Colored_MIP, Colored_outline and Gray_outline were 88.2% [95%-CI 78.7%; 94.4%], 89.5% [80.3%; 95.3%] and 78.9% [68.1%; 87.5%]; specificities were 98.7% [96.1%; 99.7%], 96.4% [93.1%; 98.5%] and 98.7% [96.1%; 99.7%]; and F1-scores were 0.918, 0.895 and 0.863, respectively. Mean time per case and rater required for evaluation was 2.8 ± 0.9 s for Colored_outline, 1.7 ± 0.1 s for Colored_MIP, and 2.0 ± 0.4 s for Gray_outline. Conclusions: The 2D segmentation mask projection images enabled the detection of segmentation errors of automated 3D segmentations of left and right lungs based on MRI with high diagnostic accuracy, especially when using color-encoding. The method enabled evaluation within a matter of seconds per case. Segmentation mask projection images may assist in visual quality control of automated segmentations in large-scale studies. Full article

Objective: Chest computed tomography (CT) is a key component of the diagnostic assessment of people with cystic fibrosis (PwCF) and is increasingly replacing chest radiography. Due to improvements in life expectancy, radiation exposure has become a growing concern in PwCF. Photon-counting CT (PCCT) has the potential to reduce the risk of radiation-induced malignancies while maintaining diagnostic accuracy. This study aimed to compare the radiation dose and image quality of low-dose high-resolution (LD-HR) and ultra-low-dose high-resolution (ULD-HR) CT protocols using PCCT in PwCF. Methods: This retrospective study included 72 PwCF, with 36 undergoing a LD-HR chest CT protocol and 36 receiving an ULD-HR protocol on a PCCT. The radiation dose and image quality were assessed by comparing the effective dose and signal-to-noise ratio (SNR). Three blinded radiologists evaluated the overall image quality, sharpness, noise, and assessability of the bronchi, bronchial wall thickening, and bronchiolitis using a five-point Likert scale. Results: The ULD-HR PCCT protocol reduced radiation exposure by approximately 65% compared with the LD-HR PCCT protocol (median effective dose: 0.19 vs. 0.55 mSv, p < 0.001). While LD-HR images were consistently rated higher than ULD-HR images (p < 0.001), both protocols maintained diagnostic significance (median image quality rating of “4-good”). The average SNR of the lung parenchyma was significantly lower with ULD-HR PCCT compared to LD-HR PCCT (p < 0.001). Conclusions: ULD-HR PCCT significantly reduced radiation exposure while maintaining good diagnostic image quality in PwCF. The effective dose of ULD-HR PCCT is only twice that of a two-plane chest X-ray, making it a viable low-radiation alternative for routine imaging in PwCF. Full article

Background: Ultrasound is the primary imaging modality for evaluating thyroid nodules, with echogenicity and nodule size serving as parameters for malignancy risk stratification. Though the TI-RADS classification system is standardized, interpretation varies among observers due to subjectivity, and can affect diagnostic consistency. This study aimed to evaluate the diagnostic and interobserver agreement of quantitative ultrasound gray-scale analysis and nodule area in differentiating benign from malignant solid thyroid nodules. Methods: This retrospective study reviewed 600 patients who underwent thyroid ultrasound at King Abdulaziz University Hospital, Jeddah, Saudi Arabia, in 2023 and 2024. Of these 600, 107 adult patients with 116 solid thyroid nodules (96 benign and 20 malignant) who subsequently underwent ultrasound-guided fine-needle aspiration were included in the final analysis. From B-mode ultrasound images, the grayscale median (GSM) values of each nodule and adjacent normal thyroid tissue were measured using Adobe Photoshop. The GSM ratio (GSMr) was calculated by dividing nodule GSM by normal tissue GSM. Nodule size, taken as cross-sectional area, was assessed using ImageJ software version 1.53. The Mann–Whitney U test was used to compare GSMr and the area between benign and malignant nodules. Inter-observer agreement was evaluated using the intraclass correlation coefficient (ICC). Results: Malignant nodules had significantly lower GSMr compared to benign nodules (malignant: median 0.76, IQR 0.27; benign: median 0.88, IQR 0.55, p = 0.02). Malignant nodules were also significantly larger than benign nodules (malignant: median 2.77 cm², IQR: 5.08; benign: median 1.78 cm², IQR 1.65, p = 0.02). Inter-observer reproducibility was excellent for both GSMr (ICC = 0.998) and area (ICC = 0.997). Conclusions: Quantitative ultrasound assessment of grayscale echogenicity and nodule area provides valuable diagnostic information for differentiating benign from malignant solid thyroid nodules. These objective measures may enhance diagnostic confidence and support more precise clinical decision-making in thyroid nodule evaluation. Full article

Objectives: Ultra-high dose-rate FLASH radiotherapy has demonstrated strong potential in reducing normal tissue toxicity while maintaining effective tumor control. However, its underlying radiobiological mechanisms remain unclear, highlighting the need for novel approaches to probe the effects of radiation during and immediately after delivery. This study presents the first exploration of 3D PET imaging of positron-emitting nuclei (PENs) generated by a FLASH proton beam. Methods: A home-built 12-panel preclinical small-animal PET system was employed for recording coincidence events. A 142.4 MeV FLASH proton beam with a 100 ms delivery time was directed into a solid water phantom. PET coincidence signals were recorded during the first 1 s and up to 11 min. The system’s capability for 3D localization was also assessed, and Monte Carlo simulations were performed for validation. Results: The PET system successfully recorded coincidence data within the first second, including the 100 ms beam delivery interval. Detector dead-time effects under the high beam flux were observed, leading to underestimated event counts. Following irradiation, the measured activity and decay behavior were consistent with simulations. The PET system accurately reconstructed the spatial distribution of PEN activities, with discrepancies in measured versus calculated line profiles ranging from 3.35–6.85%. Reconstructed PET images enabled reliable 3D localization with sub-millimeter accuracy in both lateral and depth dimensions. Conclusions: Our findings demonstrate that a multi-detector PET system is a promising tool for investigating the radiation effects of FLASH beams. Full article