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Non-Coding RNA, Volume 8, Issue 3
2022 June - 15 articles
Cover Story: Small RNA sequencing (sRNA-Seq) approaches reveal potentially functional RNA sequences derived from longer non-coding RNAs. However, RNAs shorter than 16 nucleotides (nt) are often removed from sequencing libraries/analyses, although they may be functional. Here, we compiled a comprehensive repertoire of small RNAs from 6 different eukaryotic organisms in an extended window of 8 to 30 nt RNA length. Among others, we show in this study that unusually short RNAs <16 nt appear to be more abundant than those >16 nt in bilaterian organisms. Notably, RNAs between 8 and 15 nt predominantly represent non-coding RNA fragments, such as semi-microRNAs, pRFs, sdRNAs, tRFs, and rRFs. We propose that the lower threshold of RNA length be reduced in sRNA-Seq analyses and datasets, as their abundance and diversity support their potential role as biomarkers of disease and/or mediators of cell function. View this paper
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Non-Coding RNA - ISSN 2311-553X