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Non-Coding RNA, Volume 7, Issue 4
December 2021 - 22 articles
Cover Story: Fifteen transcription factors (TF), such as IRF1, IRF2, MYC, RelA/p65, and STAT1, and 52 long non-coding RNAs (lncRNAs), such as BCDIN3D-AS1, MALAT1, NEAT1, and others, could coregulate 1066 protein-coding genes (PCG) altered in SARS-CoV-2 infected cells. Coregulated PCGs were enriched significantly with biological processes such as gene expression, mRNA splicing, the cell cycle, and the interleukin-1-mediated signaling pathway, and KEGG pathways such as ribosome, coronavirus disease, apoptosis, autophagy, MAPK signaling, the mTOR signaling pathway, and others relevant for COVID-19. Pathways related to other viral infections such as Hepatitis B, Hepatitis C, and Influenza A were also enriched significantly. Coregulation of PCG by lncRNA and TFs might play an important role in the pathogenesis of COVID-19. View this paper
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Non-Coding RNA - ISSN 2311-553X