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Non-Coding RNA, Volume 10, Issue 1
2024 February - 15 articles
Cover Story: Angiogenesis and three-dimensional vasculogenic mimicry operate in a coordinated fashion to supply cells with nutrients and oxygen required for tumor growth. However, their functions in cancer stem-like cells (CSCs) and their regulation by microRNAs remain elusive. We isolated an MDA-MB-231 (CD44+/CD24−) subpopulation of CSCs that exhibited stemness properties. The restoration of miR-204 in CSCs inhibited the formation of mammospheres, angiogenesis and hypoxia-induced vasculogenic mimicry in vitro. These inhibitory effects were associated with lower VEGFA and β-catenin levels. Our findings showed that miR-204 abrogates angiogenesis and vasculogenic mimicry in CSCs, suggesting that it could be a tool for breast cancer intervention based on microRNA replacement therapies. View this paper
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Non-Coding RNA - ISSN 2311-553X