Non-Coding RNA, Volume 8, Issue 6
December 2022 - 12 articles
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Cover Story: Resistance to hormone therapy is the leading cause of death in men with prostate cancer (PCa). In this study, the lncRNA NAALADL2-AS2 (AS2) was found to be upregulated in PCa cells challenged with androgen deprivation therapy. Quantitative PCR analysis of PCa tumor tissue showed AS2 expression to increase along disease severity with peak levels in castration-resistant PCa. AS2 transcripts were found to be confined to nucleus where it is co-expressed with the oncogene NAALADL2. Transcriptome analysis of AS2 knockdown experiments suggests this lncRNA may regulate transcriptional programs involved with glycogen metabolism and cell cycle factors. Following AS2 knockdown, a clear decrease in cell viability coupled with increased apoptosis was observed. Interestingly, AS2 knockdown did not affect NAALADL2 expression. View this paper