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Non-Coding RNA, Volume 8, Issue 6

December 2022 - 12 articles

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Cover Story: Resistance to hormone therapy is the leading cause of death in men with prostate cancer (PCa). In this study, the lncRNA NAALADL2-AS2 (AS2) was found to be upregulated in PCa cells challenged with androgen deprivation therapy. Quantitative PCR analysis of PCa tumor tissue showed AS2 expression to increase along disease severity with peak levels in castration-resistant PCa. AS2 transcripts were found to be confined to nucleus where it is co-expressed with the oncogene NAALADL2. Transcriptome analysis of AS2 knockdown experiments suggests this lncRNA may regulate transcriptional programs involved with glycogen metabolism and cell cycle factors. Following AS2 knockdown, a clear decrease in cell viability coupled with increased apoptosis was observed. Interestingly, AS2 knockdown did not affect NAALADL2 expression. View this paper

Articles (12)

  • Article
  • Open Access
1 Citations
2,919 Views
13 Pages
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The Idiopathic Pulmonary Fibrosis-Associated Single Nucleotide Polymorphism RS35705950 Is Transcribed in a MUC5B Promoter Associated Long Non-Coding RNA (AC061979.1)

  • Ruxandra Neatu,
  • Ifeanyi Enekwa,
  • Dean J. Thompson,
  • Edward C. Schwalbe,
  • Giorgio Fois,
  • Gina Abdelaal,
  • Stephany Veuger,
  • Manfred Frick,
  • Peter Braubach and
  • Sterghios A. Moschos
Non-Coding RNA2022, 8(6), 83;https://doi.org/10.3390/ncrna8060083

8 December 2022

LncRNAs are involved in regulatory processes in the human genome, including gene expression. The rs35705950 SNP, previously associated with IPF, overlaps with the recently annotated lncRNA AC061979.1, a 1712 nucleotide transcript located within the M...

Full Article
  • Brief Report
  • Open Access
6 Citations
3,252 Views
5 Pages
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Is Evolutionary Conservation a Useful Predictor for Cancer Long Noncoding RNAs? Insights from the Cancer LncRNA Census 3

  • Adrienne Vancura,
  • Alejandro H. Gutierrez,
  • Thorben Hennig,
  • Carlos Pulido-Quetglas,
  • Frank J. Slack,
  • Rory Johnson and
  • Simon Haefliger
Non-Coding RNA2022, 8(6), 82;https://doi.org/10.3390/ncrna8060082

7 December 2022

Evolutionary conservation is a measure of gene functionality that is widely used to prioritise long noncoding RNAs (lncRNA) in cancer research. Intriguingly, while updating our Cancer LncRNA Census (CLC), we observed an inverse relationship between y...

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  • Article
  • Open Access
4 Citations
3,504 Views
17 Pages
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The Androgen Regulated lncRNA NAALADL2-AS2 Promotes Tumor Cell Survival in Prostate Cancer

  • Levi Groen,
  • Viktor Yurevych,
  • Harshitha Ramu,
  • Johnny Chen,
  • Lianne Steenge,
  • Sabrina Boer,
  • Renske Kuiper,
  • Frank P. Smit,
  • Gerald W. Verhaegh and
  • Niven Mehra
  • + 1 author
Non-Coding RNA2022, 8(6), 81;https://doi.org/10.3390/ncrna8060081

1 December 2022

Castration resistance is the leading cause of death in men with prostate cancer. Recent studies indicate long noncoding RNAs (lncRNAs) to be important drivers of therapy resistance. The aim of this study was to identify differentially expressed lncRN...

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  • Article
  • Open Access
6 Citations
2,493 Views
12 Pages
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SOX2OT lncRNA Inhibition Suppresses the Stemness Characteristics of Esophageal Tumorspheres

  • Boshra Haghi,
  • Marie Saghaeian Jazi,
  • Ayyoob Khosravi,
  • Seyyed Mehdi Jafari and
  • Jahanbakhsh Asadi
Non-Coding RNA2022, 8(6), 80;https://doi.org/10.3390/ncrna8060080

28 November 2022

Background: SOX2OT is a novel cancer associated long non-coding RNA (LncRNA) with higher expression in variable tumor tissues, including esophageal squamous cell carcinoma (ESCC). It also plays an important function in embryonic neuronal development....

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  • Correction
  • Open Access
1,542 Views
2 Pages
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Correction: Tusup et al. Evaluation of the Interplay between the ADAR Editome and Immunotherapy in Melanoma. Non-Coding RNA 2021, 7, 5

  • Marina Tusup,
  • Phil F. Cheng,
  • Ernesto Picardi,
  • Austeja Raziunaite,
  • Reinhard Dummer,
  • Mitchell P. Levesque,
  • Lars E. French,
  • Emmanuella Guenova,
  • Thomas M. Kundig and
  • Steve Pascolo
Non-Coding RNA2022, 8(6), 79;https://doi.org/10.3390/ncrna8060079

21 November 2022

In the original article [...]

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  • Systematic Review
  • Open Access
3 Citations
2,461 Views
6 Pages
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Polymorphism rs2383207 of CDKN2B-AS and Susceptibility to Atherosclerosis: A Mini Review

  • Sofia Vladimorovna Timofeeva,
  • Tatiana Alexandrovna Sherchkova and
  • Tatiana Pavlovna Shkurat
Non-Coding RNA2022, 8(6), 78;https://doi.org/10.3390/ncrna8060078

18 November 2022

We conducted this meta-analysis to estimate associations between CDKN2B antisense (CDKN2B-AS) rs2383207 polymorphism and susceptibility to atherosclerosis. A systematic literature research of Google Scholar and PubMed was performed to identify eligib...

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  • Review
  • Open Access
1 Citations
3,404 Views
10 Pages
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RNA-Mediated Regulation of Meiosis in Budding Yeast

  • Vidya Vardhini Pondugala and
  • Krishnaveni Mishra
Non-Coding RNA2022, 8(6), 77;https://doi.org/10.3390/ncrna8060077

15 November 2022

Cells change their physiological state in response to environmental cues. In the absence of nutrients, unicellular fungi such as budding yeast exit mitotic proliferation and enter the meiotic cycle, leading to the production of haploid cells that are...

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  • Article
  • Open Access
4 Citations
2,826 Views
12 Pages
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The Potential of NORAD–PUMILIO–RALGAPB Regulatory Axis as a Biomarker in Breast Cancer

  • Cristiane Sato Mara Muller,
  • Igor Samesima Giner,
  • Érika Pereira Zambalde,
  • Tamyres Mingorance Carvalho,
  • Enilze Maria de Souza Fonseca Ribeiro,
  • Jaqueline Carvalho de Oliveira,
  • Carolina Mathias and
  • Daniela Fiori Gradia
Non-Coding RNA2022, 8(6), 76;https://doi.org/10.3390/ncrna8060076

10 November 2022

Introduction: Long non-coding RNAs (LncRNA) represent a heterogeneous family of RNAs that have emerged as regulators of various biological processes through their association with proteins in ribonucleoproteins complexes. The dynamic of these interac...

Full Article
  • Review
  • Open Access
18 Citations
5,417 Views
16 Pages
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Exosome RNA Sequencing as a Tool in the Search for Cancer Biomarkers

  • Marina Elkommos-Zakhary,
  • Neeraja Rajesh and
  • Vladimir Beljanski
Non-Coding RNA2022, 8(6), 75;https://doi.org/10.3390/ncrna8060075

9 November 2022

Numerous noninvasive methods are currently being used to determine biomarkers for diseases such as cancer. However, these methods are not always precise and reliable. Thus, there is an unmet need for better diagnostic and prognostic biomarkers that w...

Full Article
  • Review
  • Open Access
11 Citations
4,472 Views
16 Pages
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Navigating the Multiverse of Antisense RNAs: The Transcription- and RNA-Dependent Dimension

  • Giulia Pagani,
  • Cecilia Pandini and
  • Paolo Gandellini
Non-Coding RNA2022, 8(6), 74;https://doi.org/10.3390/ncrna8060074

26 October 2022

Evidence accumulated over the past decades shows that the number of identified antisense transcripts is continuously increasing, promoting them from transcriptional noise to real genes with specific functions. Indeed, recent studies have begun to unr...

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