Next Article in Journal
Long Non-coding RNAs Mechanisms of Action in HIV-1 Modulation and the Identification of Novel Therapeutic Targets
Previous Article in Journal
ncRNAs in Type-2 Immunity
Open AccessCommunication

NEAT1 Long Isoform Is Highly Expressed in Chronic Lymphocytic Leukemia Irrespectively of Cytogenetic Groups or Clinical Outcome

Department of Oncology and Hemato-oncology, University of Milan, 20122 Milan, Italy
Hematology, Fondazione Cà Granda IRCCS Policlinico, 20122 Milan, Italy
Mutagenesis and Cancer Prevention Unit, IRCCS Ospedale Policlinico San Martino, 16132 Genova, Italy
Molecular Pathology Unit, IRCCS Ospedale Policlinico San Martino, 16132 Genova, Italy
Hematology Unit, Department of Onco-Hematology A.O. of Cosenza, 87100 Cosenza, Italy
Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr. Aiguader 88, 08003 Barcelona, Catalonia, Spain
Department of Experimental Medicine, University of Genoa, 16126 Genoa, Italy
Unità di Ricerca Biotecnologica, Azienda Sanitaria Provinciale di Cosenza, 87051 Aprigliano (CS), Italy
Department of Hematology and Bone Marrow Transplant Unit, Augusta Victoria Hospital, 97300 Jerusalem, Israel
Author to whom correspondence should be addressed.
Non-Coding RNA 2020, 6(1), 11;
Received: 21 January 2020 / Revised: 19 February 2020 / Accepted: 8 March 2020 / Published: 13 March 2020
The biological role and therapeutic potential of long non-coding RNAs (lncRNAs) in chronic lymphocytic leukemia (CLL) are still open questions. Herein, we investigated the significance of the lncRNA NEAT1 in CLL. We examined NEAT1 expression in 310 newly diagnosed Binet A patients, in normal CD19+ B-cells, and other types of B-cell malignancies. Although global NEAT1 expression level was not statistically different in CLL cells compared to normal B cells, the median ratio of NEAT1_2 long isoform and global NEAT1 expression in CLL samples was significantly higher than in other groups. NEAT1_2 was more expressed in patients carrying mutated IGHV genes. Concerning cytogenetic aberrations, NEAT1_2 expression in CLL with trisomy 12 was lower with respect to patients without alterations. Although global NEAT1 expression appeared not to be associated with clinical outcome, patients with the lowest NEAT1_2 expression displayed the shortest time to first treatment; however, a multivariate regression analysis showed that the NEAT1_2 risk model was not independent from other known prognostic factors, particularly the IGHV mutational status. Overall, our data prompt future studies to investigate whether the increased amount of the long NEAT1_2 isoform detected in CLL cells may have a specific role in the pathology of the disease. View Full-Text
Keywords: NEAT1; Chronic Lymphocytic Leukemia; lncRNA NEAT1; Chronic Lymphocytic Leukemia; lncRNA
Show Figures

Figure 1

MDPI and ACS Style

Ronchetti, D.; Favasuli, V.; Monti, P.; Cutrona, G.; Fabris, S.; Silvestris, I.; Agnelli, L.; Colombo, M.; Menichini, P.; Matis, S.; Gentile, M.; Nurtdinov, R.; Guigó, R.; Baldini, L.; Fronza, G.; Ferrarini, M.; Morabito, F.; Neri, A.; Taiana, E. NEAT1 Long Isoform Is Highly Expressed in Chronic Lymphocytic Leukemia Irrespectively of Cytogenetic Groups or Clinical Outcome. Non-Coding RNA 2020, 6, 11.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop