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Journal of Cardiovascular Development and Disease, Volume 9, Issue 6

June 2022 - 32 articles

Cover Story: CHD is a frequent occurrence, with a prevalence of almost 1% in the general population. The pathophysiology of anomalous heart development is still unclear in most patients: a definitive genetic origin only explains 35% of identified cases. The precisely choreographed embryology of the heart relies on the timed activation of developmental molecular cascades, spatially and temporally regulated through epigenetic regulation. This network is eminently susceptible to disruption, resulting in faulty cardiac development. Similarly, the heart is unique in its dynamic development: growth is intrinsically related to mechanical stimulation, and disruption of the intrauterine environment will have a direct impact on fetal embryology. These two converging axes offer new areas of research to characterize cardiac epigenetic regulation and identify points of fragility with teratogenic potential. View this paper
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Articles (32)

  • Review
  • Open Access
13 Citations
10,509 Views
25 Pages

The onset of embryonic heart beating may be regarded as the defining feature for the beginning of personal human life. Clarifying the timing of the first human heartbeat, therefore, has religious, philosophical, ethical, and medicolegal implications....

  • Article
  • Open Access
2 Citations
2,560 Views
11 Pages

Kidney Failure among Patients with Takotsubo Syndrome or Myocardial Infarction: A Retrospective Analysis

  • Verena Bill,
  • Ibrahim El-Battrawy,
  • Marvin Kummer,
  • Andreas Mügge,
  • Assem Aweimer,
  • Michael Behnes and
  • Ibrahim Akin

Background: Takotsubo syndrome (TTS) is a syndrome with ambiguous pathophysiology. Impaired kidney function (KF) seems to impact the outcome of patients with TTS. We hypothesized that KF worsens the outcome among TTS patients and furthermore, TTS pat...

  • Review
  • Open Access
20 Citations
5,191 Views
16 Pages

Epigenetics and Congenital Heart Diseases

  • Léa Linglart and
  • Damien Bonnet

Congenital heart disease (CHD) is a frequent occurrence, with a prevalence rate of almost 1% in the general population. However, the pathophysiology of the anomalous heart development is still unclear in most patients screened. A definitive genetic o...

  • Case Report
  • Open Access
1 Citations
3,695 Views
7 Pages

Resuscitated Sudden Cardiac Arrest of a Neonate with Congenital LQT Syndrome-Associated Torsades de Pointes: A Case Report and Literature Review

  • Yen-Teng Hsu,
  • Pi-Chang Lee,
  • Yu-Hsuan Chen,
  • Shu-Jen Yeh,
  • Ming-Ren Chen,
  • Kung-Hong Hsu,
  • Chung-I Chang,
  • Wei-Ting Lai and
  • Wei-Li Hung

Sudden infant death syndrome (SIDS), the most common cause of infant death in developed countries, is attributed to diverse trigger factors. Malignant cardiac dysrhythmias are potentially treatable etiologies, and congenital long QT syndrome (LQTS) i...

  • Systematic Review
  • Open Access
11 Citations
6,228 Views
16 Pages

The Impact of Ethnicity on Athlete ECG Interpretation: A Systematic Review

  • Angus J. Davis,
  • Christopher Semsarian,
  • John W. Orchard,
  • Andre La Gerche and
  • Jessica J. Orchard

Athlete ECG interpretation criteria have been developed and refined from research in athlete populations; however, current guidelines are based on available data primarily from Caucasian and Black athletes. This study aimed to assess the impact of et...

  • Article
  • Open Access
7 Citations
4,549 Views
10 Pages

Efficacy and Safety of a Combined Aerobic, Strength and Flexibility Exercise Training Program in Patients with Implantable Cardiac Devices

  • Maria Rosaria Squeo,
  • Barbara Di Giacinto,
  • Marco Alfonso Perrone,
  • Massimo Santini,
  • Maria Luisa Sette,
  • Emanuele Fabrizi,
  • Antonia Vaquer,
  • Attilio Parisi,
  • Antonio Spataro and
  • Alessandro Biffi

Purpose: The “FIDE Project” (Fitness Implantable DEvice) was organized by the Institute of Sports Medicine and Science and the World Society of Arrhythmias with the aim of demonstrating the usefulness of exercise training in improving fun...

  • Review
  • Open Access
10 Citations
3,278 Views
11 Pages

In chronic heart failure (CHF), abnormalities in cardiac autonomic control, characterized by sympathetic overactivity, contribute to the progression of the disease and are associated with an unfavorable prognosis. Assessing cardiac autonomic status i...

  • Article
  • Open Access
2 Citations
2,695 Views
9 Pages

Evaluation of the Appropriate Use of Coronary Computed Tomography Angiography: A Retrospective, Single-Center Analysis

  • Katharina Birkl,
  • Christoph Beyer,
  • Fabian Plank,
  • Gudrun Maria Feuchtner and
  • Guy Friedrich

Purpose: We assessed the application of appropriate use criteria of coronary computed tomography angiography (CCTA) in comparison to invasive coronary angiography results and revascularization rates in patients with coronary artery disease (CAD). Met...

  • Article
  • Open Access
5 Citations
3,520 Views
12 Pages

Maternal Glycemic Spectrum and Adverse Pregnancy and Perinatal Outcomes in a Multiracial US Cohort

  • Yaa Adoma Kwapong,
  • Ellen Boakye,
  • Guoying Wang,
  • Xiumei Hong,
  • Jennifer Lewey,
  • Mamas Andreas Mamas,
  • Pensee Wu,
  • Michael Joseph Blaha,
  • Khurram Nasir and
  • Allison Gamboa Hays
  • + 3 authors

Diabetes mellitus (pregestational (PDM) and gestational (GDM)) is associated with adverse pregnancy outcomes (APOs). However, studies exploring the association of APOs with maternal glycemia among women without PDM/GDM are limited. We utilized data f...

  • Review
  • Open Access
7 Citations
5,118 Views
13 Pages

Theoretical and Practical Aspects in the Use of Bretschneider Cardioplegia

  • Claudiu Ghiragosian,
  • Marius Harpa,
  • Alexandra Stoica,
  • Flămînd Oltean Sânziana,
  • Radu Bălău,
  • Hussam Al Hussein,
  • Ghiragosian-Rusu Simina Elena,
  • Radu Mircea Neagoe and
  • Horațiu Suciu

The race for an ideal cardioplegic solution has remained enthusiastic since the beginning of the modern cardiac surgery era. The Bretschneider solution, belonging to the “intracellular cardioplegic” group, is safe and practical in myocard...

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J. Cardiovasc. Dev. Dis. - ISSN 2308-3425