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Open AccessArticle

Lipoprotein(a) Gene Polymorphism Increases a Risk Factor for Aortic Valve Calcification

1
Department of Cardiology, Faculty of Medicine, Trakya University, 22030 Edirne, Turkey
2
Department of Cardiology, Edirne Sultan 1. Murat State Hospital, 22030 Edirne, Turkey
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Department of Biophysics, Faculty of Medicine, Trakya University, 22030 Edirne, Turkey
4
Molecular Research Lab, Prof. Mirko Tos Ear and Hearing Research Center, Trakya University, 22030 Edirne, Turkey
*
Author to whom correspondence should be addressed.
J. Cardiovasc. Dev. Dis. 2019, 6(3), 31; https://doi.org/10.3390/jcdd6030031
Received: 16 July 2019 / Revised: 24 July 2019 / Accepted: 23 August 2019 / Published: 26 August 2019
Calcific aortic valve disease (CAVD) is a multifactorial condition. Both environmental and genetic factors play an important role in its etiology. CAVD exhibits a broad spectrum, varying from mild valve thickening to severe valve calcification and stenosis. Progression of the disease consists of chronic inflammation, lipoprotein deposition, and active leaflet calcification. It is a process similar to coronary artery disease. In this study, we investigated Lp(a) levels and gene polymorphisms associated with calcific aortic stenosis from blood samples after echocardiography in the evaluation of 75 patients diagnosed with CAVD and 77 controls. Blood tests were run in our laboratory to rule out certain risk factors before echocardiography examination. A significant association among smoking, elevated LDL level and creatinine, low albumin levels, Lp(a) level, rs10455872, and rs3798220 polymorphisms may be considered genetic risk factors for the development of calcific aortic stenosis. View Full-Text
Keywords: Lp(a) level; rs10455872; rs3798220; calcific aortic valve stenosis Lp(a) level; rs10455872; rs3798220; calcific aortic valve stenosis
MDPI and ACS Style

Ozkan, U.; Ozcelik, F.; Yildiz, M.; Budak, M. Lipoprotein(a) Gene Polymorphism Increases a Risk Factor for Aortic Valve Calcification. J. Cardiovasc. Dev. Dis. 2019, 6, 31.

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