Effectiveness of a Nanohydroxyapatite-Based Hydrogel on Alveolar Bone Regeneration in Post-Extraction Sockets of Dogs with Naturally Occurring Periodontitis

Tanongpitchayes, Kittidaj; Randorn, Chamnan; Lamkhao, Suphatchaya; Chokethawai, Komsanti; Rujijanagul, Gobwute; Na Lampang, Kannika; Somrup, Luddawon; Boonyapakorn, Chavalit; Thongkorn, Kriangkrai

doi:10.3390/vetsci9010007

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Effectiveness of a Nanohydroxyapatite-Based Hydrogel on Alveolar Bone Regeneration in Post-Extraction Sockets of Dogs with Naturally Occurring Periodontitis

Kittidaj Tanongpitchayes

^1,2,3,

⁴,

⁴,

⁵,

⁵,

⁶,

²,

Chavalit Boonyapakorn

^2,7,8 and

Kriangkrai Thongkorn

^2,3,7,8,*

Master’s Degree Program in Veterinary Science, Faculty of Veterinary Medicine, Chiang Mai University, Chiang Mai 50100, Thailand

Small Animal Hospital, Faculty of Veterinary Medicine, Chiang Mai University, Chiang Mai 50200, Thailand

Innovation Center for Holistic Health, Nutraceuticals, and Cosmeceuticals, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand

⁴

Department of Chemistry, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand

⁵

Department of Physics and Materials Science, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand

⁶

Department of Veterinary Bioscience and Veterinary Public Health, Faculty of Veterinary Medicine, Chiang Mai University, Chiang Mai 50100, Thailand

⁷

Department of Companion Animals and Wildlife Clinic, Faculty of Veterinary Medicine, Chiang Mai University, Chiang Mai 50100, Thailand

⁸

Integrative Research Center for Veterinary Circulatory Sciences, Faculty of Veterinary Medicine, Chiang Mai University, Chiang Mai 50100, Thailand

Author to whom correspondence should be addressed.

Academic Editors: João Filipe Martins Freire Requicha, Carlos Alberto Antunes Viegas and Fidel San Román Ascaso

Vet. Sci. 2022, 9(1), 7; https://doi.org/10.3390/vetsci9010007

Received: 24 November 2021 / Revised: 12 December 2021 / Accepted: 15 December 2021 / Published: 26 December 2021

(This article belongs to the Special Issue New insights on Veterinary Dentistry and Oral Surgery)

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Abstract

Pathological mandibular fracture after dental extraction usually occurs in dogs with moderate to severe periodontitis. A nanohydroxyapatite-based hydrogel (HAP hydrogel) was developed to diminish the limitations of hydroxyapatite for post-extraction socket preservation (PSP). However, the effect of the HAP hydrogel in dogs has still not been widely investigated. Moreover, there are few studies on PSP in dogs suffering from clinical periodontitis. The purpose of this study was to evaluate the effectiveness of the HAP hydrogel for PSP in dogs with periodontitis. In five dogs with periodontitis, the first molar (309 and 409) of each hemimandible was extracted. Consequently, all the ten sockets were filled with HAP-hydrogel. Intraoral radiography was performed on the day of operation and 2, 4, 8 and 12 weeks post operation. The Kruskal–Wallis test and paired t-test were adopted for alveolar bone regeneration analysis. The results demonstrated that the radiographic grading, bone height measurement, and bone regeneration analysis were positively significant at all follow-up times compared to the day of operation. Moreover, the scanning electron microscopy with energy-dispersive X-ray spectroscopy imaging after immersion showed a homogeneous distribution of apatite formation on the hydrogel surface. Our investigation suggested that the HAP hydrogel effectively enhances socket regeneration in dogs with periodontitis and can be applied as a bone substitute for PSP in veterinary dentistry. View Full-Text

Keywords: veterinary dentistry; veterinary periodontology; nanohydroxyapatite; hydrogel; alveolar bone regeneration; periodontitis; dogs

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MDPI and ACS Style

Tanongpitchayes, K.; Randorn, C.; Lamkhao, S.; Chokethawai, K.; Rujijanagul, G.; Na Lampang, K.; Somrup, L.; Boonyapakorn, C.; Thongkorn, K. Effectiveness of a Nanohydroxyapatite-Based Hydrogel on Alveolar Bone Regeneration in Post-Extraction Sockets of Dogs with Naturally Occurring Periodontitis. Vet. Sci. 2022, 9, 7. https://doi.org/10.3390/vetsci9010007

AMA Style

Tanongpitchayes K, Randorn C, Lamkhao S, Chokethawai K, Rujijanagul G, Na Lampang K, Somrup L, Boonyapakorn C, Thongkorn K. Effectiveness of a Nanohydroxyapatite-Based Hydrogel on Alveolar Bone Regeneration in Post-Extraction Sockets of Dogs with Naturally Occurring Periodontitis. Veterinary Sciences. 2022; 9(1):7. https://doi.org/10.3390/vetsci9010007

Chicago/Turabian Style

Tanongpitchayes, Kittidaj, Chamnan Randorn, Suphatchaya Lamkhao, Komsanti Chokethawai, Gobwute Rujijanagul, Kannika Na Lampang, Luddawon Somrup, Chavalit Boonyapakorn, and Kriangkrai Thongkorn. 2022. "Effectiveness of a Nanohydroxyapatite-Based Hydrogel on Alveolar Bone Regeneration in Post-Extraction Sockets of Dogs with Naturally Occurring Periodontitis" Veterinary Sciences 9, no. 1: 7. https://doi.org/10.3390/vetsci9010007

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Effectiveness of a Nanohydroxyapatite-Based Hydrogel on Alveolar Bone Regeneration in Post-Extraction Sockets of Dogs with Naturally Occurring Periodontitis

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