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Effect of Beta-Carotene Supplementation on the Serum Oxidative Stress Biomarker and Antibody Titer against Live Bovine Respiratory Syncytial Virus Vaccination in Japanese Black Calves

1
Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima 890-0065, Japan
2
Department of Veterinary Medicine, Kyoto Biken Laboratories, Inc., Kyoto 611-0041, Japan
*
Author to whom correspondence should be addressed.
Vet. Sci. 2018, 5(4), 102; https://doi.org/10.3390/vetsci5040102
Received: 11 October 2018 / Revised: 11 December 2018 / Accepted: 12 December 2018 / Published: 14 December 2018
The purpose of this study was to determine the effect of vaccination and beta-carotene supplementation on blood oxidative stress and antibody response in calves. Thirty Japanese Black calves were randomly assigned to two groups. Fifteen calves received 20 mg of beta-carotene supplemented into their daily provided rations from 2 to 8 weeks of age (BC group), and the other 15 calves did not receive the daily beta-carotene supplement (control group). All calves received a commercially available modified live bovine respiratory syncytial (RS) virus vaccine at 4 and 8 weeks of age. Blood samples were taken at 2, 4, 8, and 12 weeks of age. At 4 weeks of age, the concentration of reactive oxygen metabolites within serum were significantly lower in the BC group than the concentrations measured in the control group. Also at 4 weeks of age, the concentration of biological antioxidant capacity within serum was significantly higher in the BC group than the concentrations measured in the control group. Both groups showed a gradual decrease of antibody titers to live bovine RS virus in the samples taken from 2 to 12 weeks of age. These results confirmed that beta-carotene supplementation decreased oxidative stress. However, beta-carotene supplementation did not affect the antibody response to live bovine RS virus vaccination, perhaps due to the presence of the maternal antibody. View Full-Text
Keywords: antibody titer; beta-carotene; bovine respiratory syncytial virus; Japanese Black calf; oxidative stress; vaccination antibody titer; beta-carotene; bovine respiratory syncytial virus; Japanese Black calf; oxidative stress; vaccination
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MDPI and ACS Style

Otomaru, K.; Ogawa, R.; Oishi, S.; Iwamoto, Y.; Hong, H.; Nagai, K.; Hyakutake, K.; Kubota, C.; Kaneshige, T. Effect of Beta-Carotene Supplementation on the Serum Oxidative Stress Biomarker and Antibody Titer against Live Bovine Respiratory Syncytial Virus Vaccination in Japanese Black Calves. Vet. Sci. 2018, 5, 102. https://doi.org/10.3390/vetsci5040102

AMA Style

Otomaru K, Ogawa R, Oishi S, Iwamoto Y, Hong H, Nagai K, Hyakutake K, Kubota C, Kaneshige T. Effect of Beta-Carotene Supplementation on the Serum Oxidative Stress Biomarker and Antibody Titer against Live Bovine Respiratory Syncytial Virus Vaccination in Japanese Black Calves. Veterinary Sciences. 2018; 5(4):102. https://doi.org/10.3390/vetsci5040102

Chicago/Turabian Style

Otomaru, Konosuke; Ogawa, Rei; Oishi, Shoko; Iwamoto, Yuki; Hong, Hyeyoung; Nagai, Kathuhisa; Hyakutake, Koji; Kubota, Chikara; Kaneshige, Takahiro. 2018. "Effect of Beta-Carotene Supplementation on the Serum Oxidative Stress Biomarker and Antibody Titer against Live Bovine Respiratory Syncytial Virus Vaccination in Japanese Black Calves" Vet. Sci. 5, no. 4: 102. https://doi.org/10.3390/vetsci5040102

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