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Serum Levels of Neuropeptides in Cows with Left Abomasal Displacement

1
Clinic for Obstetrics, Gynecology and Andrology of Large and Small Animals with Ambulatory Service, Faculty of Veterinary Medicine, Justus-Liebig-University, 35392 Giessen, Germany
2
Institute of Veterinary Physiology, Faculty of Veterinary Medicine, Justus-Liebig-University, 35392 Giessen, Germany
3
Biomathematics and Data Processing Unit, Faculty of Veterinary Medicine, Justus-Liebig-University, 35392 Giessen, Germany
*
Author to whom correspondence should be addressed.
Vet. Sci. 2018, 5(4), 103; https://doi.org/10.3390/vetsci5040103
Received: 3 December 2018 / Accepted: 13 December 2018 / Published: 17 December 2018
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Abstract

Abomasal displacement (AD) to the left is a common disease in high-yielding dairy cows after parturition. In view of the previously reported changes in tissue neuropeptide concentrations in cows with AD, the primary aim of this study was to evaluate the effect of AD and breed on serum neuropeptide concentrations. For this purpose, blood samples of 33 German Holstein (GH) cows with AD, 36 healthy controls (GH), and 32 healthy German Fleckvieh (GF) cows were collected, and concentrations of substance P (SP), vasoactive intestinal polypeptide (VIP), and interleukin1β (IL-1β) were measured via commercially available ELISA kits. To examine the effect of AD, we compared GH cows with and without AD and observed no significant effects of AD on SP, VIP, or Il-1 β concentrations. To evaluate the effect of breed, we compared healthy GH with healthy GF cows and detected markedly higher VIP serum levels in the healthy GF cows (p < 0.01). No significant differences in SP or IL-1β were detected. According to our results, there seems to be no effect of AD on the serum concentrations of SP, VIP, or IL-1 β. In contrast, there seems to be a breed difference concerning serum VIP concentrations. View Full-Text
Keywords: dairy cattle; left abomasal displacement; serum; substance P; VIP dairy cattle; left abomasal displacement; serum; substance P; VIP
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Sickinger, M.; Roth, J.; Failing, K.; Wehrend, A. Serum Levels of Neuropeptides in Cows with Left Abomasal Displacement. Vet. Sci. 2018, 5, 103.

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