Evaluation of Anesthetic and Cardiorespiratory Effects after Intramuscular Administration of Three Different Doses of Telazol® in Common Marmosets (Callithrix jacchus)
Abstract
:Simple Summary
Abstract
1. Introduction
2. Materials and Methods
2.1. Animals, Housing, and Husbandry
2.2. Study Method and Data Analysis
3. Results
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Posture | |
Score | Assessment |
0 | Recumbency without spontaneous movement |
1 | Recumbency with spontaneous movement of the head or limbs |
2 | Sitting or standing, unstable |
3 | Sitting or standing, stable |
Muscular Tension | |
Score | Assessment |
0 | Complete muscle relaxation, all limbs have no muscle contraction |
1 | Partial muscle relaxation, one or more limbs have muscle contraction |
2 | Normal muscle tension, all limbs have muscle contraction |
Pedal Withdrawal Reflex | |
Score | Assessment |
0 | No reflex; no bending of the knee during or one second after the removal of the hemostat |
1 | Normal reflex; bending of the knee in response |
2 | Increased reflex; increased muscle tension and bending of the knee with muscle movements of the other limbs |
Palpebral Reflex | |
Score | Assessment |
0 | No reflex; no response of the eye lid |
1 | Decreased reflex; partial closing of the eye lid |
2 | Normal reflex: eye lid immediately closes fully |
Outcome | Dose Comparison | Mean Difference | Lower CL | Upper CL | p Value |
---|---|---|---|---|---|
Induction | 5–10 | 0.9 | 0.34 | 1.46 | 0.00351 |
Induction | 5–15 | 1.2 | 0.64 | 1.76 | 0.00029 |
Induction | 10–15 | 0.3 | −0.26 | 0.86 | 0.515 |
Immobilization | 5–10 | −11.3 | −32.94 | 10.34 | 0.287 |
Immobilization | 5–15 | −30.1 | −51.74 | −8.46 | 0.0091 |
Immobilization | 10–15 | −18.8 | −40.44 | 2.84 | 0.085 |
Recovery | 5–10 | −19.8 | −37.84 | −1.76 | 0.033 |
Recovery | 5–15 | −35.9 | −53.94 | −17.86 | 0.00056 |
Recovery | 10–15 | −16.1 | −34.14 | 1.94 | 0.077 |
Total | 5–10 | −30.2 | −49.67 | −10.73 | 0.0044 |
Total | 5–15 | −64.8 | −84.27 | −45.33 | 0.0000016 |
Total | 10–15 | −34.6 | −54.07 | −15.13 | 0.0015 |
5 mg/kg Telazol® | 10 mg/kg Telazol® | 15 mg/kg Telazol® | |
---|---|---|---|
Spontaneous movement | 37.7 min after injection | 52 min | 60.7 min |
Normal muscle tension (score of 2) | 28.5 ± 18.46 min (median) after injection | 49 ± 29.49 min | 52.5 ± 33.17 min |
Pedal withdrawal reflex (score of 1) | 9.5 ± 10.07 min after injection | 10.5 ± 15.15 min | 22 ± 14.39 min |
Palpebral reflex (score of 1 or 2) | 8 ± 4.82 min after injection | 7.5 ± 1.89 min | 8 ± 2.4 min |
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Goodroe, A.; Bakker, J.; Remarque, E.J.; Ross, C.N.; Scorpio, D. Evaluation of Anesthetic and Cardiorespiratory Effects after Intramuscular Administration of Three Different Doses of Telazol® in Common Marmosets (Callithrix jacchus). Vet. Sci. 2023, 10, 116. https://doi.org/10.3390/vetsci10020116
Goodroe A, Bakker J, Remarque EJ, Ross CN, Scorpio D. Evaluation of Anesthetic and Cardiorespiratory Effects after Intramuscular Administration of Three Different Doses of Telazol® in Common Marmosets (Callithrix jacchus). Veterinary Sciences. 2023; 10(2):116. https://doi.org/10.3390/vetsci10020116
Chicago/Turabian StyleGoodroe, Anna, Jaco Bakker, Edmond J. Remarque, Corinna N. Ross, and Diana Scorpio. 2023. "Evaluation of Anesthetic and Cardiorespiratory Effects after Intramuscular Administration of Three Different Doses of Telazol® in Common Marmosets (Callithrix jacchus)" Veterinary Sciences 10, no. 2: 116. https://doi.org/10.3390/vetsci10020116