Next Article in Journal
Finite Element Simulation and Additive Manufacturing of Stiffness-Matched NiTi Fixation Hardware for Mandibular Reconstruction Surgery
Next Article in Special Issue
pH-Responsive Mesoporous Silica and Carbon Nanoparticles for Drug Delivery
Previous Article in Journal
Biodegradable Polymeric Substances Produced by a Marine Bacterium from a Surplus Stream of the Biodiesel Industry
Open AccessArticle

Biosilica from Living Diatoms: Investigations on Biocompatibility of Bare and Chemically Modified Thalassiosira weissflogii Silica Shells

Italian National Council for Research—Institute for the Chemistry of OrganoMetallic Compounds (CNR-ICCOM)-Bari, Bari 70126, Italy
Department of Chemistry, Università degli Studi di Bari Aldo Moro, Bari 70121, Italy
CNR-Nanotech, Lecce 73100, Italy
Author to whom correspondence should be addressed.
Academic Editor: Chiara Vitale-Brovarone
Bioengineering 2016, 3(4), 35;
Received: 10 November 2016 / Revised: 2 December 2016 / Accepted: 7 December 2016 / Published: 16 December 2016
In the past decade, mesoporous silica nanoparticles (MSNs) with a large surface area and pore volume have attracted considerable attention for their application in drug delivery and biomedicine. Here we propose biosilica from diatoms as an alternative source of mesoporous materials in the field of multifunctional supports for cell growth: the biosilica surfaces were chemically modified by traditional silanization methods resulting in diatom silica microparticles functionalized with 3-mercaptopropyl-trimethoxysilane (MPTMS) and 3-aminopropyl-triethoxysilane (APTES). Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy analyses revealed that the –SH or –NH2 were successfully grafted onto the biosilica surface. The relationship among the type of functional groups and the cell viability was established as well as the interaction of the cells with the nanoporosity of frustules. These results show that diatom microparticles are promising natural biomaterials suitable for cell growth, and that the surfaces, owing to the mercapto groups, exhibit good biocompatibility. View Full-Text
Keywords: diatoms; biosilica; cell growth diatoms; biosilica; cell growth
Show Figures

Graphical abstract

MDPI and ACS Style

Cicco, S.R.; Vona, D.; Gristina, R.; Sardella, E.; Ragni, R.; Lo Presti, M.; Farinola, G.M. Biosilica from Living Diatoms: Investigations on Biocompatibility of Bare and Chemically Modified Thalassiosira weissflogii Silica Shells. Bioengineering 2016, 3, 35.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop