Table of Contents
Toxics, Volume 5, Issue 1 (March 2017)
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Cover Story (view full-size image) Endocrine disrupting chemicals (EDCs) are exogenous agents that have the capacity to behave as [...] Read more. Endocrine disrupting chemicals (EDCs) are exogenous agents that have the capacity to behave as biological signals and interfere with/or mimic estrogenic hormones. Environmental relevant concentrations can induce micronucleus formation and interfere with cell-division processes, with associated transcriptional alterations in chromosome segregation genes, and interferes with senescence in primary vascular endothelial cells (HUVEC). The aneugenic potential can be observed in the image representative of immunofluorescence results of in situ detection of α-tubulin (red) showing senescent HUVEC cells, with DNA loss, after continuous exposure to 4µ of BPA (693h). DNA is DAPI stained (blue).