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Inorganics 2019, 7(1), 2; https://doi.org/10.3390/inorganics7010002

Nano-Based Systems and Biomacromolecules as Carriers for Metallodrugs in Anticancer Therapy

1
Department of Chemistry, Brooklyn College, The City University of New York, 2900 Bedford Avenue, Brooklyn, NY 11210, USA
2
Ph.D. Program in Biochemistry, The Graduate Center of the City University of New York, New York, NY 10016, USA
3
Ph.D. Program in Chemistry, The Graduate Center of the City University of New York, New York, NY 10016, USA
*
Author to whom correspondence should be addressed.
Received: 1 November 2018 / Revised: 7 December 2018 / Accepted: 11 December 2018 / Published: 20 December 2018
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Abstract

Since the discovery of cisplatin and its potency in anticancer therapy, the development of metallodrugs has been an active area of research. The large choice of transition metals, oxidation states, coordinating ligands, and different geometries, allows for the design of metal-based agents with unique mechanisms of action. Many metallodrugs, such as titanium, ruthenium, gallium, tin, gold, and copper-based complexes have been found to have anticancer activities. However, biological application of these agents necessitates aqueous solubility and low systemic toxicity. This minireview highlights the emerging strategies to facilitate the in vivo application of metallodrugs, aimed at enhancing their solubility and bioavailability, as well as improving their delivery to tumor tissues. The focus is on encapsulating the metal-based complexes into nanocarriers or coupling to biomacromolecules, generating efficacious anticancer therapies. The delivery systems for complexes of platinum, ruthenium, copper, and iron are discussed with most recent examples. View Full-Text
Keywords: metallodrugs; nanoparticles; dendrimers; nanotubes; liposomes; biomacromolecules; encapsulation; targeting; micelles metallodrugs; nanoparticles; dendrimers; nanotubes; liposomes; biomacromolecules; encapsulation; targeting; micelles
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Poursharifi, M.; Wlodarczyk, M.T.; Mieszawska, A.J. Nano-Based Systems and Biomacromolecules as Carriers for Metallodrugs in Anticancer Therapy. Inorganics 2019, 7, 2.

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