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Inorganics, Volume 7, Issue 1

January 2019 - 11 articles

Cover Story: Cancer is known to be one of the deadliest diseases in the world. Nowadays, chemotherapeutic treatment with cisplatin is commonly used, However, based on its severe side effects as well as observed resistance, its clinical use is limited. To overcome these issues, there is an urgent need for the development of novel anticancer agents. Herein, we present the preparation, characterization and in-depth biological investigation of Fe(II) polypyridine complexes as potential drug candidates for chemotherapy and photodynamic therapy (PDT). These complexes were found to absorb in the red region, enabling deeper penetration during light treatment. The compounds were stable in human plasma and photostable upon continuous LED irradiation. Importantly, one of these complexes showed toxicity in the low micromolar range in the dark as well as some phototoxicity upon irradiation against cervical cancer cells. View Paper here.
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Articles (11)

  • Review
  • Open Access
28 Citations
6,255 Views
13 Pages

Magnetic resonance imaging (MRI) is a powerful non-invasive diagnostic tool that can provide important insights for medical treatment monitoring and optimization. Photodynamic therapy (PDT), a minimally invasive treatment for various types of tumors,...

  • Article
  • Open Access
3 Citations
3,993 Views
15 Pages

Softening the Donor-Set: From [Cu(P^P)(N^N)][PF6] to [Cu(P^P)(N^S)][PF6]

  • Isaak Nohara,
  • Alessandro Prescimone,
  • Catherine E. Housecroft and
  • Edwin C. Constable

We report the synthesis and characterization of [Cu(P^P)(N^S)][PF6] complexes with P^P = bis(2-(diphenylphosphino)phenyl) ether (POP) or 4,5-bis(diphenylphosphino)-9,9- dimethylxanthene (xantphos) and N^S = 2-(iso-propylthio)pyridine (iPrSpy) or 2-(t...

  • Article
  • Open Access
11 Citations
4,854 Views
20 Pages

We have theoretically studied the formation of hydrogen-bonded (HB) and halogen-bonded (XB) complexes of halogen oxoacids (HXOn) with Lewis bases (NH3 and Cl−) at the CCSD(T)/CBS//RIMP2/aug-cc-pVTZ level of theory. Minima structures have been f...

  • Article
  • Open Access
30 Citations
5,635 Views
36 Pages

The enzyme nitrogenase naturally hydrogenates N2 to NH3, achieved through the accumulation of H atoms on FeMo-co, the Fe7MoS9C(homocitrate) cluster that is the catalytically active site. Four intermediates, E1H1, E2H2, E3H3, and E4H4, carry these hyd...

  • Article
  • Open Access
7 Citations
4,667 Views
10 Pages

Tetrazolato-bridged dinuclear platinum(II) complexes ([{cis-Pt(NH3)2}2(μ-OH)(μ-5-R-tetrazolato-N2,N3)]2+; tetrazolato-bridged complexes) are a promising source of next-generation platinum-based drugs. β-Cyclodextrin (β-CD) forms inclu...

  • Article
  • Open Access
28 Citations
6,367 Views
15 Pages

Cancer is known to be one of the major causes of death nowadays. Among others, chemotherapy with cisplatin is a commonly used treatment. Although widely employed, cisplatin is known to cause severe side effects, such as nerve and kidney damage, nause...

  • Article
  • Open Access
5 Citations
5,601 Views
12 Pages

Synthesis and Reactivity of Mn–CF3 Complexes

  • Alex L. Daniels,
  • Jason G. Da Gama,
  • Racquel Edjoc,
  • Bulat M. Gabidullin and
  • R. Tom Baker

The synthesis, characterization and reactivity of several bi- and tridentate, N-ligated manganese carbonyl trifluoromethyl complexes are presented. These complexes exhibit elongated Mn–CCF3 bonds (versus Mn(CF3)(CO)5), suggesting a lability tha...

  • Article
  • Open Access
4 Citations
3,568 Views
10 Pages

The HIV nucleocapsid protein NCp7 was previously shown to play a number of roles in the viral life cycle and was previously identified as a potential target for small molecule intervention. In this work, the synthesis of the previously unreported com...

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Inorganics - ISSN 2304-6740