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Article

The Efficacy of Photobiomodulation Therapy in Improving Tissue Resilience and Healing of Radiation Skin Damage

1
Oral Biology, Biomedical Engineering and Surgery, School of Dental Medicine, University at Buffalo, 3435 Main Street, Buffalo, NY 14214, USA
2
Energetic and Nuclear Research Institute (IPEN/CNEN-SP)–CR–Radiation Center, Ave. Lineu Prestes, 2242 Cidade Universitária, São Paulo 05508-000, Brazil
3
Energetic and Nuclear Research Institute (IPEN/CNEN-SP)–CLA–Center for Laser and Applications, Ave. Lineu Prestes, 2242 Cidade Universitária, São Paulo 05508-000, Brazil
4
Energetic and Nuclear Research Institute (IPEN/CNEN-SP)–CTR–Radiation Technology Center, São Paulo 05508-000, Brazil
5
Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro 21941-590, Brazil
*
Author to whom correspondence should be addressed.
Photonics 2022, 9(1), 10; https://doi.org/10.3390/photonics9010010
Received: 29 November 2021 / Revised: 19 December 2021 / Accepted: 23 December 2021 / Published: 28 December 2021
The increased precision, efficacy, and safety of radiation brachytherapy has tremendously improved its popularity in cancer care. However, an unfortunate side effect of this therapy involves localized skin damage and breakdown that are managed palliatively currently. This study was motivated by prior reports on the efficacy of photobiomodulation (PBM) therapy in improving tissue resilience and wound healing. We evaluated the efficacy of PBM therapy on 36 athymic mice with 125I seed (0.42 mCi) implantation over 60 days. PBM treatments were performed with either red (660 nm) or near-infrared (880 nm, NIR) LEDs irradiance of 40 mW/cm2, continuous wave, fluence of 20 J/cm2 once per week. Animals were evaluated every 7 days with digital imaging, laser Doppler flowmetry, thermal imaging, µPET-CT imaging using 18F-FDG, and histology. We observed that both PBM treatments—red and NIR—demonstrated significantly less incidence and severity and improved healing with skin radionecrosis. Radiation exposed tissues had improved functional parameters such as vascular perfusion, reduced inflammation, and metabolic derangement following PBM therapy. Histological analysis confirmed these observations with minimal damage and resolution in tissues exposed to radiation. To our knowledge, this is the first report on the successful use of PBM therapy for brachytherapy. The results from this study support future mechanistic lab studies and controlled human clinical studies to utilize this innovative therapy in managing side effects from radiation cancer treatments. View Full-Text
Keywords: photobiomodulation therapy; brachytherapy; radiation wounds; LED; µPET-CT photobiomodulation therapy; brachytherapy; radiation wounds; LED; µPET-CT
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MDPI and ACS Style

Mosca, R.C.; Santos, S.N.; Nogueira, G.E.C.; Pereira, D.L.; Costa, F.C.; Pereira, J.X.; Zeituni, C.A.; Arany, P.R. The Efficacy of Photobiomodulation Therapy in Improving Tissue Resilience and Healing of Radiation Skin Damage. Photonics 2022, 9, 10. https://doi.org/10.3390/photonics9010010

AMA Style

Mosca RC, Santos SN, Nogueira GEC, Pereira DL, Costa FC, Pereira JX, Zeituni CA, Arany PR. The Efficacy of Photobiomodulation Therapy in Improving Tissue Resilience and Healing of Radiation Skin Damage. Photonics. 2022; 9(1):10. https://doi.org/10.3390/photonics9010010

Chicago/Turabian Style

Mosca, Rodrigo C., Sofia N. Santos, Gesse E.C. Nogueira, Daisa L. Pereira, Francielli C. Costa, Jonathas X. Pereira, Carlos A. Zeituni, and Praveen R. Arany. 2022. "The Efficacy of Photobiomodulation Therapy in Improving Tissue Resilience and Healing of Radiation Skin Damage" Photonics 9, no. 1: 10. https://doi.org/10.3390/photonics9010010

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