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Dermatopathology, Volume 11, Issue 1

March 2024 - 13 articles

Cover Story: Galli–Galli disease is a rare autosomal dominant genodermatosis typically presenting with erythematous macules, papules, and reticulated hyperpigmentation of the flexural areas. A distinct atypical variant is characterized by brown macules on the trunk and extremities without the characteristic reticulated hyperpigmentation. This review examines cases since the disease was first described and summarizes current knowledge regarding its etiology, clinical presentation, histopathology, diagnosis, and treatment. We review the genetic, histopathologic, and clinical similarities between Galli–Galli disease and Dowling–Degos disease, another rare genodermatosis, focusing on the common mutations in KRT5 and POGLUT1. We support the hypothesis that the two diseases may be different phenotypic expressions of the same pathological condition, although traditionally recognized as separate entities. View this paper

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Articles (13)

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Case Report

2,751 Views

6 Pages

A Case of Pleomorphic Dermal Sarcoma: Giant Exophytic Tumor of the Medial Canthus

Rylee Moody,
Kavita Darji,
Tricia A. Missall,
Peter Chow and
Ramona Behshad

Dermatopathology2024, 11(1), 13-18;https://doi.org/10.3390/dermatopathology11010003

29 December 2023

We present the case of a 99-year-old Caucasian female who was referred for treatment of a painless, 8.0 cm × 7.8 cm exophytic, pedunculated, ulcerated tumor of the left medial canthus. Pathology showed spindled, oval, and polygonal cells with p...

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Case Report

2 Citations

5,680 Views

5 Pages

Perforating Fibrous Histiocytoma Mimicking Keratoacanthoma: A Case Report

Alina Lungu,
Aurélie Hsieh,
Gürkan Kaya and
Sébastien Menzinger

Dermatopathology2024, 11(1), 8-12;https://doi.org/10.3390/dermatopathology11010002

25 December 2023

A 31-year-old male presented with a firm, well-demarcated, erythematous, crateriform, and ulcerated nodule in the left lumbar region, which persisted for 3 months. Clinically, a keratoacanthoma was suspected. The histological analysis was consistent...

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Communication

1 Citations

2,258 Views

7 Pages

Claudin-4 Upregulation in Acantholytic and Autoimmune-Mediated Bullous Disorders

Chau M. Bui,
Huy G. Vuong,
Minh-Khang Le,
Kristin J. Rybski,
Hatice B. Zengin,
Haiming Tang and
Bruce R. Smoller

Dermatopathology2024, 11(1), 1-7;https://doi.org/10.3390/dermatopathology11010001

21 December 2023

Claudin-4 is a key component of tight junctions, which play an important role in the formation of the epidermal barrier by forming a circumferential network in the granular layer that serves as a gatekeeper of the paracellular pathway. The aim of thi...

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Dermatopathology - ISSN 2296-3529

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