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The Advantages of Polymeric Hydrogels in Calcineurin Inhibitor Delivery

1
Instituto de Ciencias Químicas Aplicadas, Facultad de Ingeniería, Universidad Autónoma de Chile, Av. Pedro de Valdivia 425, Santiago 7500912, Chile
2
Departamento de Pediatría y Cirugía Infantil Sur, Facultad de Medicina, Universidad de Chile, Av. Miguel Carrera 3100, Santiago 8900085, Chile
3
Laboratorio de Fisiopatología Renal, Instituto de Ciencias Biomédicas, Universidad Autónoma de Chile, El Llano Subercaseux 2801, Santiago 8910060, Chile
*
Author to whom correspondence should be addressed.
Processes 2020, 8(11), 1331; https://doi.org/10.3390/pr8111331
Received: 31 August 2020 / Revised: 16 September 2020 / Accepted: 12 October 2020 / Published: 22 October 2020
(This article belongs to the Special Issue Polymeric Hydrogels for Biomedical Applications)
In recent years, polymeric hydrogels (PolyHy) have been extensively explored for their applications in biomedicine as biosensors, in tissue engineering, diagnostic processes, and drug release. The physical and chemical properties of PolyHy indicate their potential use in regulating drug delivery. Calcineurin inhibitors, particularly cyclosporine (CsA) and tacrolimus (TAC), are two important immunosuppressor drugs prescribed upon solid organ transplants. Although these drugs have been used since the 1970s to significantly increase the survival of transplanted organs, there are concerns regarding their undesirable side effects, primarily due to their highly variable concentrations. In fact, calcineurin inhibitors lead to acute and chronic toxicities that primarily cause adverse effects such as hypertension and nephrotoxicity. It is suggested from the evidence that the encapsulation of calcineurin inhibitors into PolyHy based on polysaccharides, specifically alginate (Alg), offers effective drug delivery with a stable immunosuppressive response at the in vitro and in vivo levels. This not only may reduce the adverse effects but also would improve the adherence of the patients by the effective preservation of drug concentrations in the therapeutic ranges. View Full-Text
Keywords: polymeric hydrogels; drug delivery; calcineurin inhibitors; cyclosporine; tacrolimus polymeric hydrogels; drug delivery; calcineurin inhibitors; cyclosporine; tacrolimus
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Sandoval-Yañez, C.; Escobar, L.; Amador, C.A. The Advantages of Polymeric Hydrogels in Calcineurin Inhibitor Delivery. Processes 2020, 8, 1331.

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