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Adverse-Mode FFF: Multi-Force Ideal Retention Theory
by
Tyler N. Shendruk 1,* and Gary W. Slater 2
Tyler N. Shendruk 1,* and Gary W. Slater 2
1
The Rudolf Peierls Centre for Theoretical Physics, 1 Keble Road, Oxford OX1 3NP, UK
2
Department of Physics, University of Ottawa, 150 Louis-Pasteur, Ottawa, ON K1N 6N5, Canada
*
Author to whom correspondence should be addressed.
Academic Editor: Ronald Beckett
Chromatography 2015, 2(3), 392-409; https://doi.org/10.3390/chromatography2030392
Received: 31 May 2015 / Revised: 25 June 2015 / Accepted: 29 June 2015 / Published: 7 July 2015
(This article belongs to the Special Issue Field-Flow Fractionation)
A novel field-flow fractionation (FFF) technique, in which two opposing external forces act on the solute particles, is proposed. When the two external forces are sufficiently strong and scale differently as a function of the solutes’ property of interest (such as the solute particle size), a sharp peak in the retention ratio (dramatic drop in elution time) is predicted to exist. Because the external forces oppose one another, we refer to this novel technique as adverse-mode FFF. The location of this peak is theoretically predicted and its ideal width estimated. The peak can become quite sharp by simultaneously increasing the strength of both fields, suggesting that adverse-mode FFF could be a useful technique for accurately measuring single species solute size.
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Keywords:
field-flow fractionation; separation; theory
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MDPI and ACS Style
Shendruk, T.N.; Slater, G.W. Adverse-Mode FFF: Multi-Force Ideal Retention Theory. Chromatography 2015, 2, 392-409.
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