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The Measurement of Asthma and Allergic Rhinitis Control in Children and Adolescents
Open AccessCommunication

Pragmatic Markers in the Management of Asthma: A Real-World-Based Approach

Allergy Clinic, Casa di Cura Villa Montallegro, Via P. Boselli 5, 16146 Genoa, Italy
Pediatric Clinic, Department of Pediatrics, Fondazione IRCCS Policlinico San Matteo, University of Pavia, 27100 Pavia, Italy
Department of Clinical and Biological Sciences, University of Turin, San Luigi Gonzaga University Hospital, 10043 Turin, Italy
Pediatric Allergy Center, Istituto Giannina Gaslini, 16100 Genoa, Italy
Author to whom correspondence should be addressed.
Children 2020, 7(5), 48;
Received: 2 April 2020 / Revised: 12 May 2020 / Accepted: 13 May 2020 / Published: 18 May 2020
(This article belongs to the Special Issue Pediatric Asthma)
Bronchial hyperreactivity, reversible airflow limitation and chronic airway inflammation characterize asthma pathophysiology. Personalized medicine, i.e., a tailored management approach, is appropriate for asthma management and is based on the identification of peculiar phenotypes and endotypes. Biomarkers are necessary for defining phenotypes and endotypes. Several biomarkers have been described in asthma, but most of them are experimental and/or not commonly available. The current paper will, therefore, present pragmatic biomarkers useful for asthma management that are available in daily clinical practice. In this regard, eosinophil assessment and serum allergen-specific IgE assay are the most reliable biomarkers. Lung function, mainly concerning forced expiratory flow at 25-755 of vital capacity (FEF25-75), and nasal cytology may be envisaged as ancillary biomarkers in asthma management. In conclusion, biomarkers have clinical relevance in asthma concerning both the endotype definition and the personalization of the therapy. View Full-Text
Keywords: asthma; biomarkers; phenotype; endotype; personalized therapy asthma; biomarkers; phenotype; endotype; personalized therapy
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Ciprandi, G.; Marseglia, G.L.; Ricciardolo, F.L.M.; Tosca, M.A. Pragmatic Markers in the Management of Asthma: A Real-World-Based Approach. Children 2020, 7, 48.

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