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Article

Lower Functional and Proportional Characteristics of Cord Blood Treg of Male Newborns Compared with Female Newborns

1
Institute of Immunology and Microbiology, First Faculty of Medicine, Charles University, 121 08 Prague, Czech Republic
2
Institute for the Care of Mother and Child, 147 00 Prague, Czech Republic
*
Author to whom correspondence should be addressed.
Academic Editor: Marie Černá
Biomedicines 2021, 9(2), 170; https://doi.org/10.3390/biomedicines9020170
Received: 31 December 2020 / Revised: 1 February 2021 / Accepted: 4 February 2021 / Published: 9 February 2021
(This article belongs to the Special Issue Epigenetic Regulation of the Immune System)
Understanding the early events involved in the induction of immune tolerance to harmless environmental antigens and microbiota compounds could reveal potential targets for allergic disease therapy or prevention. Regulatory T cells (Treg), particularly induced Treg (iTreg), are crucial for the induction and maintenance of tolerance against environmental antigens including allergens. A decrease in the number and/or function of Treg or iTreg could represent an early predictor of allergy development. We analyzed proportional and functional properties of Treg in the cord blood of children of allergic mothers (neonates at high risk of allergy development) and healthy mothers (neonates with relatively low risk of allergy development). We observed a higher number of induced Treg in the cord blood of females compared to males, suggesting an impaired capacity of male immunity to set up tolerance to allergens, which could contribute to the higher incidence of allergy observed in male infants. The decreased proportion of iTreg in cord blood compared with maternal peripheral blood documents the general immaturity of the neonatal immune system. We observed a positive correlation in the demethylation of the Treg-specific demethylated region (TSDR) and the proportion of Treg in cord blood. Our data suggest that immaturity of the neonatal immune system is more severe in males, predisposing them to increased risk of allergy development. View Full-Text
Keywords: regulatory T cells; allergy; cord blood; induced Treg; natural Treg; flow cytometry; Helios; epigenetics; TSDR regulatory T cells; allergy; cord blood; induced Treg; natural Treg; flow cytometry; Helios; epigenetics; TSDR
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MDPI and ACS Style

Černý, V.; Novotná, O.; Petrásková, P.; Hudcová, K.; Boráková, K.; Prokešová, L.; Kolářová, L.; Hrdý, J. Lower Functional and Proportional Characteristics of Cord Blood Treg of Male Newborns Compared with Female Newborns. Biomedicines 2021, 9, 170. https://doi.org/10.3390/biomedicines9020170

AMA Style

Černý V, Novotná O, Petrásková P, Hudcová K, Boráková K, Prokešová L, Kolářová L, Hrdý J. Lower Functional and Proportional Characteristics of Cord Blood Treg of Male Newborns Compared with Female Newborns. Biomedicines. 2021; 9(2):170. https://doi.org/10.3390/biomedicines9020170

Chicago/Turabian Style

Černý, Viktor, Olga Novotná, Petra Petrásková, Kateřina Hudcová, Kristýna Boráková, Ludmila Prokešová, Libuše Kolářová, and Jiří Hrdý. 2021. "Lower Functional and Proportional Characteristics of Cord Blood Treg of Male Newborns Compared with Female Newborns" Biomedicines 9, no. 2: 170. https://doi.org/10.3390/biomedicines9020170

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