Special Issue "Epigenetic Regulation of the Immune System"
A special issue of Biomedicines (ISSN 2227-9059).
Deadline for manuscript submissions: 30 June 2020.
The term epigenetics was first introduced by Conrad Waddington in 1942. For long half century, it was not quite clear its significance in gene expression, cell differentiation and heritability. Until modern technologies of the beginning of the 21st century have opened a new area of research. Epigenetic modifications of the genome allow reaction of cells to external signals by alternation of gene activity, by modifying gene expression. Epigenome, in fact, controls accessibility of DNA for transcription factors that regulate level of gene expression. By this way epigenetic regulations are responsible for the cell differentiation that is so critical in the immune system.
Innate and adaptive immune responses are components of an integrated system of host defense in which numerous cells and molecules function cooperatively. Immune responses are regulated by a system of positive feedback loops that amplify the reaction and by control mechanisms that prevent inappropriate or pathologic reactions. All regulations are under control of epigenetic mechanisms.
Immunity declines during ageing, as shown by the increased susceptibility to infection. Deterioration of immune reactions mirrors alteration of cell function, particularly T lymphocytes. With aging there is progressive accumulation of epigenetic damage as a direct consequence of evolved limitations in the genetic and epigenetic settings of maintenance and repair functions.
We encourage to submit research and review papers about the epigenetic modulation in various immune responses. We believe that this Special Issue will reflect the new exciting era of epigenetics and show its role in the immune function.
Dr. Marie Černá
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- immune responses
- innate immunity
- adaptive immunity
- cell differentiation
- cellular senescence
- gene expression
- DNA methylation
- histone modifications
- RNA-mediated gene silencing