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Open AccessArticle

Regulatory Effects of Skate Skin-Derived Collagen Peptides with Different Molecular Weights on Lipid Metabolism in the Liver and Adipose Tissue

by Minji Woo 1,2 and Jeong Sook Noh 3,*
1
Busan Innovation Institute of Industry, Science & Technology Planning (BISTEP), Busan 48058, Korea
2
Department of Food Science and Nutrition and Kimchi Research Institute, Pusan National University, Busan 46241, Korea
3
Department of Food Science and Nutrition, Tongmyong University, Busan 48520, Korea
*
Author to whom correspondence should be addressed.
Biomedicines 2020, 8(7), 187; https://doi.org/10.3390/biomedicines8070187
Received: 20 May 2020 / Revised: 27 June 2020 / Accepted: 29 June 2020 / Published: 30 June 2020
This study investigated the effects of skate skin collagen peptide (SSCP) with different molecular weights (MWs) on the lipid metabolism in the liver and adipose tissue. Male db/db mice were orally administered with water (control group) or low SSCP (LCP group) or high SSCP (HCP group) MW for 8 weeks whereas male m/m mice were used for comparison (normal group) (n = 10 each group). Compared to the control group, the LCP and HCP groups had lower adipose tissue mass, plasma and hepatic lipid concentrations, and plasma leptin levels (p < 0.05). Protein expression levels of lipogenesis-related protein were reduced in both liver and adipose tissues of SSCP-fed groups whereas those for lipolysis were elevated (p < 0.05). In particular, the LCP had the higher effects relative to the HCP. The above results were supported by histological analysis, revealing that SSCP administration decreased the size of adipose droplets and suppressed hepatic lipid accumulation. Our results showed that SSCP has potential antiobesity properties through the improvement of lipid metabolism in the liver and adipose tissue; in particular, the lower MW of collagen peptide had the greater effects.
Keywords: collagen; skate skin; obesity; lipid metabolism; liver; adipose tissue collagen; skate skin; obesity; lipid metabolism; liver; adipose tissue
MDPI and ACS Style

Woo, M.; Noh, J.S. Regulatory Effects of Skate Skin-Derived Collagen Peptides with Different Molecular Weights on Lipid Metabolism in the Liver and Adipose Tissue. Biomedicines 2020, 8, 187.

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