The Role of Angiogenesis in Cancer Treatment
Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Rensselaer, NY 12144, USA
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Biomedicines 2017, 5(2), 34; https://doi.org/10.3390/biomedicines5020034
Received: 2 May 2017
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Revised: 9 June 2017
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Accepted: 15 June 2017
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Published: 21 June 2017
(This article belongs to the Special Issue Anti-Angiogenesis Therapeutics in Cancer)
A number of anti-angiogenesis drugs have been FDA-approved and are being used in cancer treatment, and a number of other agents are in different stages of clinical development or in preclinical evaluation. However, pharmacologic anti-angiogenesis strategies that arrest tumor progression might not be enough to eradicate tumors. Decreased anti-angiogenesis activity in single mechanism-based anti-angiogenic strategies is due to the redundancy, multiplicity, and development of compensatory mechanism by which blood vessels are remodeled. Improving anti-angiogenesis drug efficacy will require identification of broad-spectrum anti-angiogenesis targets. These strategies may have novel features, such as increased porosity, and are the result of complex interactions among endothelial cells, extracellular matrix proteins, growth factors, pericyte, and smooth muscle cells. Thus, combinations of anti-angiogenic drugs and other anticancer strategies such as chemotherapy appear essential for optimal outcome in cancer patients. This review will focus on the role of anti-angiogenesis strategies in cancer treatment.
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Keywords:
physiological angiogenesis; pathological angiogenesis; pro-angiogenesis; anti-angiogenesis; endothelial cells; pericyte; integrin; matrix metalloproteinase; vascular growth factors; anti-VEGF; anti-integrin; tyrosine kinase inhibitors
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MDPI and ACS Style
Rajabi, M.; Mousa, S.A. The Role of Angiogenesis in Cancer Treatment. Biomedicines 2017, 5, 34. https://doi.org/10.3390/biomedicines5020034
AMA Style
Rajabi M, Mousa SA. The Role of Angiogenesis in Cancer Treatment. Biomedicines. 2017; 5(2):34. https://doi.org/10.3390/biomedicines5020034
Chicago/Turabian StyleRajabi, Mehdi, and Shaker A. Mousa. 2017. "The Role of Angiogenesis in Cancer Treatment" Biomedicines 5, no. 2: 34. https://doi.org/10.3390/biomedicines5020034
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