You are currently viewing a new version of our website. To view the old version click .

Biomedicines, Volume 13, Issue 1

January 2025 - 247 articles

Cover Story: Diabetes, which affects over 530 million adults worldwide, is characterized by the loss of functional pancreatic β-cells, primarily through apoptosis. This review examines the roles of the anti-apoptotic proteins Bcl-2 and Bcl-xL, which are critical regulators of the intrinsic apoptosis pathway. In addition to their role in apoptosis, these proteins influence intracellular Ca2+ homeostasis and mitochondrial metabolism, making them essential for β-cell survival and function. Dysregulation of Bcl-2 and Bcl-xL contributes to β-cell dysfunction, thereby accelerating the progression of diabetes. This article emphasizes the importance of maintaining proper levels of Bcl-2 and Bcl-xL in β-cells and explores potential therapeutic strategies targeting these proteins to preserve functional β-cell mass and combat diabetes. View this paper
  • Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
  • You may sign up for email alerts to receive table of contents of newly released issues.
  • PDF is the official format for papers published in both, html and pdf forms. To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Reader to open them.

Articles (247)

  • Review
  • Open Access
2 Citations
3,296 Views
19 Pages

Assessment of IL-6 Pathway Inhibition in Gastrointestinal Behçet’s Disease from Immunological and Clinical Perspectives

  • Makoto Naganuma,
  • Mitsuhiro Takeno,
  • Aykut Ferhat Çelik,
  • Robert Moots,
  • Philippe Pinton and
  • Tadakazu Hisamatsu

Behçet’s disease is an autoinflammatory disorder characterized by relapsing and remitting vasculitis that can manifest in various forms, including gastrointestinal Behçet’s disease (GIBD). Its complications (e.g., intestinal...

  • Review
  • Open Access
6 Citations
3,408 Views
20 Pages

The Role of Air Pollution and Olfactory Dysfunction in Alzheimer’s Disease Pathogenesis

  • Louise Odendaal,
  • Hazel Quek,
  • Carla Cuní-López,
  • Anthony R. White and
  • Romal Stewart

The escalating issue of air pollution contributes to an alarming number of premature fatalities each year, thereby posing a significant threat to global health. The focus of recent research has shifted towards understanding its potential association...

  • Article
  • Open Access
2,713 Views
13 Pages

Bacterial Diversity in Native Heart Valves in Infective Endocarditis

  • Anna Sinitskaya,
  • Alexander Kostyunin,
  • Maxim Asanov,
  • Maria Khutornaya,
  • Anastasia Klyueva,
  • Alyona Poddubnyak,
  • Alexey Tupikin,
  • Marsel Kabilov and
  • Maxim Sinitsky

Background: Infective endocarditis (IE) is an infectious disease caused by the hematogenous dissemination of bacteria into heart valves. Improving the identification of pathogens that cause IE is important to increase the effectiveness of its therapy...

  • Article
  • Open Access
2 Citations
1,808 Views
17 Pages

Perfusate Liver Arginase 1 Levels After End-Ischemic Machine Perfusion Are Associated with Early Allograft Dysfunction

  • Giuseppina Basta,
  • Serena Babboni,
  • Daniele Pezzati,
  • Serena Del Turco,
  • Emanuele Balzano,
  • Gabriele Catalano,
  • Lara Russo,
  • Giovanni Tincani,
  • Paola Carrai and
  • Stefania Petruccelli
  • + 11 authors

Background/Objectives: The rising use of liver grafts from donation after circulatory death (DCD) has been enabled by advances in normothermic regional perfusion (NRP) and machine perfusion (MP) technologies. We aimed to identify predictive biomarker...

  • Article
  • Open Access
1 Citations
1,628 Views
18 Pages

Palm Tocotrienol Activates the Wnt3a/β-Catenin Signaling Pathway, Protecting MC3T3-E1 Osteoblasts from Cellular Damage Caused by Dexamethasone and Promoting Bone Formation

  • Norfarahin Abdullah Sani,
  • Nur Aqilah Kamaruddin,
  • Ima Nirwana Soelaiman,
  • Kok-Lun Pang,
  • Kok-Yong Chin and
  • Elvy Suhana Mohd Ramli

Background and aim: Prolonged glucocorticoid (GC) treatment increases oxidative stress, triggers apoptosis of osteoblasts, and contributes to osteoporosis. Tocotrienol, as an antioxidant, could protect the osteoblasts and preserve bone quality under...

  • Article
  • Open Access
2 Citations
1,517 Views
13 Pages

Background/Objectives: This study aimed to evaluate the clinical characteristics and identify the prognostic factors affecting visual outcomes, retinal detachment, and recurrence in cytomegalovirus retinitis (CMVR) patients following allogeneic hemat...

  • Review
  • Open Access
11 Citations
6,855 Views
25 Pages

Environmental Pollutants as Emerging Concerns for Cardiac Diseases: A Review on Their Impacts on Cardiac Health

  • Vinay Kumar,
  • Hemavathy S,
  • Lohith Kumar Dasarahally Huligowda,
  • Mridul Umesh,
  • Pritha Chakraborty,
  • Basheer Thazeem and
  • Anand Prakash Singh

Comorbidities related to cardiovascular disease (CVD) and environmental pollution have emerged as serious concerns. The exposome concept underscores the cumulative impact of environmental factors, including climate change, air pollution, chemicals li...

  • Review
  • Open Access
6 Citations
6,939 Views
72 Pages

Natural Cyclic Peptides: Synthetic Strategies and Biomedical Applications

  • Devan Buchanan,
  • Shogo Mori,
  • Ahmed Chadli and
  • Siva S. Panda

Natural cyclic peptides, a diverse class of bioactive compounds, have been isolated from various natural sources and are renowned for their extensive structural variability and broad spectrum of medicinal properties. Over 40 cyclic peptides or their...

  • Review
  • Open Access
2 Citations
7,614 Views
25 Pages

A Biopsychosocial Overview of Speech Disorders: Neuroanatomical, Genetic, and Environmental Insights

  • Diya Jaishankar,
  • Tanvi Raghuram,
  • Bhuvanesh Kumar Raju,
  • Divyanka Swarna,
  • Shriya Parekh,
  • Narendra Chirmule and
  • Vikramsingh Gujar

Speech disorders encompass a complex interplay of neuroanatomical, genetic, and environmental factors affecting individuals’ communication ability. This review synthesizes current insights into the neuroanatomy, genetic underpinnings, and envir...

  • Article
  • Open Access
1 Citations
2,282 Views
16 Pages

Intra- and Interspecies Conjugal Transfer of Plasmids in Gram-Negative Bacteria

  • Julia R. Savelieva,
  • Daria A. Kondratieva and
  • Maria V. Golikova

Background/Objectives: Plasmid-mediated resistance is a significant mechanism that contributes to the gradual decrease in the efficacy of antibiotics from various classes, including carbapenems. The aim of this study is to investigate the frequency o...

of 25

Get Alerted

Add your email address to receive forthcoming issues of this journal.

XFacebookLinkedIn
Biomedicines - ISSN 2227-9059