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Open AccessReview

Development of Systems for the Production of Plant-Derived Biopharmaceuticals

1
Plant Systems Engineering Research Center, Korea Research Institute of Bioscience and Biotechnology, 125 Gwahak-ro, Yuseong-gu, Daejeon 34141, Korea
2
Department of Biological Sciences, Chungnam National University, 99 Deahank-ro, Yuseong-gu, Daejeon 34134, Korea
3
National Research Safety Headquarters, Korea Research Institute of Bioscience and Biotechnology, 30 Yeongudanji-ro, Ochang, Chungbuk-do 28116, Korea
*
Author to whom correspondence should be addressed.
Plants 2020, 9(1), 30; https://doi.org/10.3390/plants9010030
Received: 13 November 2019 / Revised: 20 December 2019 / Accepted: 23 December 2019 / Published: 24 December 2019
(This article belongs to the Special Issue Plant Expression Systems for Bioproduct Production)
Over the last several decades, plants have been developed as a platform for the production of useful recombinant proteins due to a number of advantages, including rapid production and scalability, the ability to produce unique glycoforms, and the intrinsic safety of food crops. The expression methods used to produce target proteins are divided into stable and transient systems depending on applications that use whole plants or minimally processed forms. In the early stages of research, stable expression systems were mostly used; however, in recent years, transient expression systems have been preferred. The production of the plant itself, which produces recombinant proteins, is currently divided into two major approaches, open-field cultivation and closed-indoor systems. The latter encompasses such regimes as greenhouses, vertical farming units, cell bioreactors, and hydroponic systems. Various aspects of each system will be discussed in this review, which focuses mainly on practical examples and commercially feasible approaches. View Full-Text
Keywords: molecular farming; plant-derived protein; recombinant protein; expression system; production system molecular farming; plant-derived protein; recombinant protein; expression system; production system
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MDPI and ACS Style

Moon, K.-B.; Park, J.-S.; Park, Y.-I.; Song, I.-J.; Lee, H.-J.; Cho, H.S.; Jeon, J.-H.; Kim, H.-S. Development of Systems for the Production of Plant-Derived Biopharmaceuticals. Plants 2020, 9, 30.

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