Unanswered Questions Regarding Sex and BMP/TGF-β Signaling
AbstractCrosstalk between the BMP and TGF-β signaling pathways regulates many complex developmental processes from the earliest stages of embryogenesis throughout adult life. In many situations, the two signaling pathways act reciprocally. For example, TGF-β signaling is generally pro-fibrotic, whereas BMP signaling is anti-fibrotic and pro-calcific. Sex-specific differences occur in many diseases including cardiovascular pathologies. Differing ratios of fibrosis and calcification in stenotic valves suggests that BMP/TGF-β signaling may vary in men and women. In this review, we focus on the current understanding of the interplay between sex and BMP/TGF-β signaling and pose several unanswered questions. View Full-Text
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Shah, T.A.; Rogers, M.B. Unanswered Questions Regarding Sex and BMP/TGF-β Signaling. J. Dev. Biol. 2018, 6, 14.
Shah TA, Rogers MB. Unanswered Questions Regarding Sex and BMP/TGF-β Signaling. Journal of Developmental Biology. 2018; 6(2):14.Chicago/Turabian Style
Shah, Tapan A.; Rogers, Melissa B. 2018. "Unanswered Questions Regarding Sex and BMP/TGF-β Signaling." J. Dev. Biol. 6, no. 2: 14.
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