Next Article in Journal
Effect of Antifreeze Glycoproteins on Organoid Survival during and after Hypothermic Storage
Previous Article in Journal
Diagnostic Value of Soluble Urokinase-Type Plasminogen Activator Receptor in Addition to High-Sensitivity Troponin I in Early Diagnosis of Acute Myocardial Infarction
Article Menu
Issue 3 (March) cover image

Export Article

Open AccessArticle
Biomolecules 2019, 9(3), 109; https://doi.org/10.3390/biom9030109

Antimicrobial Films Based on Nanocomposites of Chitosan/Poly(vinyl alcohol)/Graphene Oxide for Biomedical Applications

1
Escuela de Ingeniería de Materiales, Facultad de Ingeniería, Universidad del Valle, Calle 13 No. 100-00, Santiago de Cali 760032, Colombia
2
Grupo de Investigación Biotecnología, Facultad de Ingeniería, Universidad de San Buenaventura Cali, Carrera 122 # 6-65, Cali 76001, Colombia
3
Escuela de Odontología, Grupo Biomateriales Dentales, Universidad del Valle, Calle 13 No. 100-00, Cali 76001, Colombia
4
Laboratorio SIMERQO, Departamento de Química, Universidad del Valle, Calle 13 No. 100-00, Cali 76001, Colombia
5
Programa de Química, Facultad de Ciencias, Universidad del Atlántico, Carrera 30 No. 8-49, Puerto Colombia 081008, Colombia
*
Author to whom correspondence should be addressed.
Received: 18 February 2019 / Revised: 10 March 2019 / Accepted: 11 March 2019 / Published: 18 March 2019
(This article belongs to the Section Molecular Medicine)
  |  
PDF [6592 KB, uploaded 27 March 2019]
  |  

Abstract

Today, tissue regeneration is one of the greatest challenges in the field of medicine, since it represents hope after accidents or illnesses. Tissue engineering is the science based on improving or restoring tissues and organs. In this work, five formulations of chitosan/poly(vinyl alcohol)/graphene oxide (CS/PVA/GO) nanocomposites were studied for the development of biodegradable films with potential biomedical applications. The characterization of the films consisted of Fourier-transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM) and energy dispersive spectroscopy (EDS). The antibacterial activity was evaluated in vitro against Gram-positive bacteria Bacillus cereus and Staphylococcus aureus and Gram-negative Salmonella spp. and Escherichia coli, by contact of the film above inoculum bacterial in Müeller–Hinton agar. On the other hand, in vivo tests in which the material implanted in the subcutaneous tissue of Wistar rats demonstrated that the formulation CS/PVA/GO (14.25:85:0.75) was the best antibacterial film with adequate degradation in vivo. All together, these results indicate the potential of the films using nanocomposites of CS/PVA/GO in tissue engineering and cell regeneration. View Full-Text
Keywords: biodegradable films; chitosan; graphene oxide; poly(vinyl alcohol); tissue engineering biodegradable films; chitosan; graphene oxide; poly(vinyl alcohol); tissue engineering
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material

SciFeed

Share & Cite This Article

MDPI and ACS Style

Ruiz, S.; Tamayo, J.A.; Delgado Ospina, J.; Navia Porras, D.P.; Valencia Zapata, M.E.; Mina Hernandez, J.H.; Valencia, C.H.; Zuluaga, F.; Grande Tovar, C.D. Antimicrobial Films Based on Nanocomposites of Chitosan/Poly(vinyl alcohol)/Graphene Oxide for Biomedical Applications. Biomolecules 2019, 9, 109.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Biomolecules EISSN 2218-273X Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top