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Biomolecules 2019, 9(3), 108; https://doi.org/10.3390/biom9030108

Diagnostic Value of Soluble Urokinase-Type Plasminogen Activator Receptor in Addition to High-Sensitivity Troponin I in Early Diagnosis of Acute Myocardial Infarction

1
Department of General and Interventional Cardiology, University Heart Center, 20246 Hamburg, Germany
2
German Center for Cardiovascular Research (DZHK), Partner Site Hamburg, Lübeck, Kiel, Hamburg, 20246 Hamburg, Germany
*
Author to whom correspondence should be addressed.
Both authors contributed equally.
Received: 26 January 2019 / Revised: 8 March 2019 / Accepted: 14 March 2019 / Published: 18 March 2019
(This article belongs to the Special Issue Biomolecules for Translational Approaches in Cardiology)
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Abstract

The soluble urokinase-type plasminogen activator receptor (suPAR) is a new marker for immune activation and inflammation and may provide diagnostic value on top of established biomarkers in patients with suspected acute myocardial infarction (AMI). Here, we evaluate the diagnostic potential of suPAR levels on top of high-sensitivity troponin I (hs-TnI) in a cohort of patients with suspected AMI. A total of 1220 patients presenting to the emergency department with suspected AMI were included, of whom 245 were diagnosed with AMI. Median suPAR levels at admission were elevated in subjects with AMI compared to non-AMI (3.8 ng/mL vs. 3.3 ng/mL, p = 0.001). In C-statistics, the area under the curve (AUC) regarding the diagnosis of AMI was low (0.57 at an optimized cut-off of 3.7 ng/mL). Moreover, baseline suPAR levels on top of troponin values at admission and hour 1 reduced the number of patients who were correctly ruled-out as non-AMI, and who were correctly ruled-in as AMI. Our study shows that circulating levels of suPAR on top of high-sensitivity troponin I do not improve the early diagnosis of AMI. View Full-Text
Keywords: suPAR; troponin; diagnosis; acute coronary syndrome suPAR; troponin; diagnosis; acute coronary syndrome
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Sörensen, N.A.; Dönmez, G.; Neumann, J.T.; Nikorowitsch, J.; Rübsamen, N.; Blankenberg, S.; Westermann, D.; Zeller, T.; Karakas, M. Diagnostic Value of Soluble Urokinase-Type Plasminogen Activator Receptor in Addition to High-Sensitivity Troponin I in Early Diagnosis of Acute Myocardial Infarction. Biomolecules 2019, 9, 108.

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