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Technical Note

Compression of Large Sets of Sequence Data Reveals Fine Diversification of Functional Profiles in Multigene Families of Proteins: A Study for Peptidyl-Prolyl cis/trans Isomerases (PPIase)

Retired from: Service d’Ingénierie Moléculaire des Protéines (SIMOPRO), CEA-Université Paris-Saclay, F-91191 Gif/Yvette, France
Biomolecules 2019, 9(2), 59; https://doi.org/10.3390/biom9020059
Received: 21 December 2018 / Revised: 21 January 2019 / Accepted: 30 January 2019 / Published: 11 February 2019
In this technical note, we describe analyses of more than 15,000 sequences of FK506-binding proteins (FKBP) and cyclophilins, also known as peptidyl-prolyl cis/trans isomerases (PPIases). We have developed a novel way of displaying relative changes of amino acid (AA)-residues at a given sequence position by using heat-maps. This type of representation allows simultaneous estimation of conservation level in a given sequence position in the entire group of functionally-related paralogues (multigene family of proteins). We have also proposed that at least two FKBPs, namely FKBP36, encoded by the Fkbp6 gene and FKBP51, encoded by the Fkbp5 gene, can form dimers bound via a disulfide bridge in the nucleus. This type of dimer may have some crucial function in the regulation of some nuclear complexes at different stages of the cell cycle. View Full-Text
Keywords: FKBP; cyclophilin; PPIase; heat-map; immunophilin FKBP; cyclophilin; PPIase; heat-map; immunophilin
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MDPI and ACS Style

Galat, A. Compression of Large Sets of Sequence Data Reveals Fine Diversification of Functional Profiles in Multigene Families of Proteins: A Study for Peptidyl-Prolyl cis/trans Isomerases (PPIase). Biomolecules 2019, 9, 59. https://doi.org/10.3390/biom9020059

AMA Style

Galat A. Compression of Large Sets of Sequence Data Reveals Fine Diversification of Functional Profiles in Multigene Families of Proteins: A Study for Peptidyl-Prolyl cis/trans Isomerases (PPIase). Biomolecules. 2019; 9(2):59. https://doi.org/10.3390/biom9020059

Chicago/Turabian Style

Galat, Andrzej. 2019. "Compression of Large Sets of Sequence Data Reveals Fine Diversification of Functional Profiles in Multigene Families of Proteins: A Study for Peptidyl-Prolyl cis/trans Isomerases (PPIase)" Biomolecules 9, no. 2: 59. https://doi.org/10.3390/biom9020059

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