Systematic Review of Binge Eating Rodent Models for Developing Novel or Repurposing Existing Pharmacotherapies
Abstract
:1. Introduction
2. Materials and Methods
3. Results
3.1. Study Charactersitics and Selection
3.2. Biogenic Amines and Related Compounds
Adrenergic/Noradrenergic | |||
Study | Methods | Details | Major Findings |
Hicks et al., 2020 [50] | Species: Rat Binge Food: Chocolate-flavored high-sucrose (50% kcal) AIN-76A-based pellets Access: 1 h Frequency: Daily Duration: >12 days Calorie Restriction: None | Male Wistar rats were training to nose poke for binge food or standard chow pellets on fixed ratio and progressive ratio (PR) testing. The dose-dependent effects of prazosin (0.5–2 mg/kg; IP) on binge food responding were assessed. |
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Bello et al., 2014 [43] | Species: Rat Binge Food: Vegetable shortening blended with 10% sucrose Access: 30 min Frequency: 2 non-consecutive days per week Duration: 6 weeks Calorie Restriction: Two groups of rats had a 24-h calorie restriction prior to the binge period twice a week (Restrict). | Female Sprague Dawley rats were exposed to the binge eating paradigm with or without intermittent calorie restriction. c-Fos immunoreactivity was measured in the medial prefrontal cortex (mPFC) and hypothalamic paraventricular nucleus (PVN) in response to binge food, with or without acute restraint stress (1 h). In another set of experiments, female rats were implanted with an osmotic minipump to provide a sustained release of guanfacine, alpha adrenergic 2A receptor agonist (0.5 mg/kg/day) or vehicle to determine the effects of binge food intake. |
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Bello et al., 2014 [44] | Species: Rat Binge Food: Vegetable shortening blended with 10% sucrose Access: 30 min Frequency: 2 non-consecutive days per week Duration: 10 weeks Calorie Restriction: Two groups had a 24 h calorie restriction prior to the binge period twice a week. (Restrict) | Male Sprague Dawley rats were exposed to the binge eating paradigm with or without intermittent calorie restriction. Noradrenergic involvement was assessed by feeding suppression to a selective norepinephrine reuptake inhibitor, nisoxetine (3 mg/kg; IP), dorsal noradrenergic bundle lesions with neurotoxin (DSP4), and single-unit electrophysiological recording of locus coeruleus (LC) neurons. |
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Dopaminergic | |||
Study | Methods | Details | Major Findings |
Presby et al., 2020 [51] | Species: Rat Binge Food: Ground Cadbury’s Dairy Milk Chocolate Access: 2 h Frequency: 12 non-consecutive days (1–3 days apart) Duration: 4 weeks Calorie Restriction: 85% of ad libitum feeding weights for 18 weeks. After that, 18 weeks of ad libitum feeding and normal weight before starting the binge feeding protocol. | Female Wistar rats were exposed to standard lab chow and divided into three groups, +chocolate, +standard chow, and +empty feeding dish. Effects of lisdexamfetamine (LDX; 0.185–1.5 mg/kg; IP) on operant responding and intake were measured. |
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Vickers et al., 2017 [47] | Species: Rat Binge Food: Ground chocolate (Cadbury’s Dairy Milk) Access: 2 h Frequency: Intermittent on Days 1, 2, 4, 6, 7, 9, 12, 14, 15, 18, 23, 25 and 28. Duration: >28 days Calorie Restriction: None | Female Wistar were trained on operant delay discounting lever pressing task (immediate vs. delayed reward) before exposure to the binge eating paradigm. Rats were dosed in a cross-over design with oral lisdexamfetamine (LDX; 0.3 mg/kg or 0.8 mg/kg) or vehicle after 2 weeks on the binge eating paradigm. |
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Heal et al., 2016 [46] | Species: Rat Binge Food: Ground chocolate (Cadbury’s Dairy Milk) Access: 2 h Frequency: Intermittent on Days 1, 2, 4, 6, 7, 9, 12, 14, 15, 18, 23, 25 and 28. Duration: >28 days Calorie Restriction: None | Female Wistar were exposed to the binge eating paradigm or no access to binge food (control) and trained on conditioned avoidance response task. Binge or control rats were dosed with lisdexamfetamine (LDX: 0.8 mg/kg) or vehicle to assess performance in novel food reward/punishment conflict paradigm. |
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Halpern et al., 2013 [42] | Species: Mouse Binge Food: High-fat diet (HFD; 60% fat, 20% carbohydrates, 20% protein) Access: 1 h Frequency: Daily Duration: 8 days (3 days; 5 treatment days) Calorie Restriction: None | Male C57BL/6J mice were implanted unilaterally into the left nucleus accumbens shell (NAS), core or dorsal striatum with a bipolar tungsten electrode. Mice were exposed to the binge eating paradigm and deep brain stimulation (DBS) with 150 µA on two non-consecutive days. Pharmacological blockage of DBS with D1R antagonist (SCH-23390, 0.075 mg/kg; IP) or D2 antagonist (raclopride; 3 mg/kg; IP) was also performed. |
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Serotonergic | |||
Study | Methods | Details | Major Findings |
Karth et al., 2022 [53] | Species: Mouse Binge Food: High-fat diet (39.7% Fat) Access: 24 h Frequency: Once per week Duration: >3 weeks Calorie Restriction: None | Male and female mice homozygous for a knockin (KI) of tryptophan hydroxylase 2 (Tph2; R439H) or littermate contols (WT). Tph2 KI mice have reduced (~60–80%) serotonin levels. FLX was administered acutely (30 mg/kg; or saline; IP) or chronically (150 mg/L or unadulterated drinking water) for 21 days. Serotonin-related gene expression was measured by qPCR from the raphe nucleus. |
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Blumenthal and Pratt, 2018 [48] | Species: Rat Binge Food: Vegetable shortening Access: 2 h Frequency: Daily Duration: ~22 days Calorie Restriction: None | Male Sprague Dawley rats were implanted with bilateral intracranial cannulas targeting the nucleus accumbens core. Rats received vehicle or DAMGO (mu-opioid receptor agonist; 0.025 μg) prior to the binge access. In addition, rats received fenfluramine (0, 0.6, or 3.0 mg/kg; IP) or lorcaserin (0, 0.3, or 1.0 mg/kg; IP). |
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Price et al., 2018 [49] | Species: Rat Binge Food: High-fat diet (45%) Access: 2 h Frequency: Once per week Duration: 5–9 weeks Calorie Restriction: None | Adult male Sprague Dawley rats were IP administered a novel 5HT-2cR agonist, WAY163909, 0.5, 1.0 or 2.0 mg/Kg) prior to binge access. |
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Chandler-Laney et al., 2007 [41] | Species: Rat Binge food: Double-Stuff Oreo cookies Access: 3 cycles of restriction–refeeding, each lasting 12 days. Refeeding consisted of presentation of cookies for a short period, followed by ad lib chow. Frequency: 12-day cycle: 5 days ad lib chow or restriction, 2 days ad lib chow and cookies, 4 days ad lib chow, 1 day stress/no stress. Duration: 6 cycles of 12 days of restriction/refeeding followed by a test day on day 13. Calorie Restriction: 66% of ad libitum standard chow. Stress: Acute foot shock. | Female Sprague Dawley rats were exposed to a binge paradigm with or without stress or restriction. The central effects of FLX (3 mg/kg;IP) on binge eating were asseseed. Levels of serotonin, dopamine, and metabolites were evaluated from key brain regions involved in feeding and reward. Serotonin, dopamine, norepinephrine, and their metabolites were measured using high-performance liquid chromatography (HPLC). |
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Placidi et al., 2004 [38] | Species: Rat Binge food: Nabisco Oreo cookies (4.7 kcal/g; 57%, 40%, and 3% of kcal from carbohydrates, fats, and protein, respectively. Access: 24 h Frequency: After every R-R/S cycle the animals had access to binge food and standard chow. Ad libitum access during test period. Duration: ~2 months Calorie Restriction: 4 days of 66% of control food intake followed by 6 days of free feeding (R + NS and R + S groups). | Female Sprague Dawley rats were exposed to binge paradigm with or without stress (i.e., acute foot shock; 0.6 mA). The role of serotonergic function in binge eating behaviors was investigated, specifically the influence of FLX (2 mg/kg; IP). |
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GABAergic | |||
Study | Methods | Details | Major Findings |
Wojnicki et al., 2006 [40] | Species: Rat Binge food: Crisco All-Vegetable shortening Access: 1 h Frequency: Daily (D) or intermittent (INT) 3 days/week. Duration: 4–6 months Calorie Restriction: None | Operant performance of 18 non-food deprived male Sprague Dawley rats was assessed under progressive ratio (PR) and concurrent PR-fixed ratio schedules of chow pellets and/or vegetable shortening reinforcement. Rats were then divided into 2 groups based on schedule of binge food access: High-Restriction binge group (1 h access 3 days/week) and Low-Restriction binge group (1 h access daily). The effects of (R)-baclofen (0.3, 0.6, 1.0 and 1.8 mg/kg) on operant performance were assessed. |
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Buda-Levin et al., 2005 [39] | Species: Rat Binge food: Vegetable shortening, chow + shortening mixture. Access: Vegetable shortening for 2 h on Monday, Wednesday, and Friday (MWF), continuous access to chow + shortening mixture, or standard chow alone. Frequency: Daily (D) or Intermittent (INT) on non-consecutive days, 3 days a week. Duration: ~4 months Calorie Restriction: None (30 min post-injection) | Male Sprague Dawley rats were divided into 3 groups: Binge (B), Fat-Matched (FM), and Chow (C) groups. Animals were exposed to binge food in INT or D. The effect of the GABA-B agonist, baclofen (0, 0.3, 0.6, 1.0, 1.8 mg/kg IP), was assessed for the reduction of binge food intake. |
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Glutamatergic | |||
Study | Methods | Details | Major Findings |
Oliveira et al., 2021 [52] | Species: Mouse Binge Food: High-fat diet: (45% fat) Access: Ad libitum, assesed 2.5 h after caloric restriction. Frequency: Daily Duration: 15 weeks Calorie Restriction: One period of 14 h food deprivation at week 12 prior to drug treatment. | The metabotropic glutamate receptor 5 (mGluR5) is known to modulate central reward pathways. The effect of the mGluR5 negative allosteric modulator VU0409106 (3, 7.5, or 15 mg/kg) or FLX (10 mg.kg) in regulating feeding and obesity parameters in diet-induced obese C57BL/6 mice was assessed. Food intake, body weight, inflammatory/hormonal levels, and behavioral tests were measured/performed. |
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Smith et al., 2015 [45] | Species: Rat Binge Food: Chocolate-flavored high-sucrose (50% kcal) AIN-76A-based pellets Access: 1 h Frequency: Daily Duration: >12 days Calorie Restriction: None | Male Wistar rats were trained on binge eating paradigm to operant respond (FR1) for binge food. Rats were administered an uncompetitive N-methyl-D-Aspartate antagonist, memantine (0, 1.25, 2.5, 5, and 10 mg/kg, IP), 30 min prior to the binge food or standard diet access. Another group of rats had cannula targeting the nucleus accumbens (NAcc) core or shell and received (0, 2.5, 10, and 20 µg/side) immediately before access. |
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3.2.1. Noradrenergic/Adrenergic-Acting Compounds
3.2.2. Dopaminergic-Acting Compounds
3.2.3. Serotonergic-Acting Compounds
3.2.4. γ-Aminobutyric Acid (GABA)-Ergic Compounds
3.2.5. Glutamatergic Compounds
3.3. Opioidergic Compounds
3.4. Hormone Analogs
3.4.1. Estrogenic Compounds
3.4.2. Corticotropin-Releasing Factor (CRF) and Stress-Related Compounds
3.4.3. Gut Peptide Analogs
3.5. Additional Individual Compounds
Opioidergic | |||
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Study | Methods | Details | Major Findings |
Blasio et al., 2014 [54] | Species: Rat Binge Food: Chocolate-flavored high-sucrose (50% kcal) AIN-76A-based pellets Access: 1 h Frequency: Daily Duration: >12 days Calorie Restriction: None | Male Wistar rats were administered naloxone (0.03–0.3 mg/kg, SQ) or microinfused (5 µg or 25 µg/side) into the nucleus accumbens (NAcc) shell or medial frontal cortex (mPFC) to assess FR1 or breakpoint for binge food. Gene expression of opioid-related genes (POMC, PDyn and PEnk) was assessed in NAcc or mPFC. |
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Giuliano et al., 2012 [56] | Species: Rat Binge food: Chocolate-flavored pellets Access: 1 h chow access followed by 2 h food deprivation, 10 min access to chow feeder, and 10 min access to another chow feeder. Frequency: 15 consecutive days (preference) Duration: >2 months Calorie Restriction: 18 g/day lab chow for two weeks prior to the food-seeking experiment. | Male and female Lister Hooded rats were exposed to binge eating and food-seeking paradigms. The effects of the novel mu-opioid receptor antagonists, GSK1521498 (0.1, 1, and 3 mg/kg; SC) or Naltrexone (NTX, 0.1, 1, and 3 mg/kg; SC), on food seeking behavior (measured in rats trained to respond for reward under a second-order schedule of reinforcement) and binge-like eating were assessed. |
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Naleid et al., 2007 [58] | Species: Rat Binge food: Choice of fat diet (77% fat) or sucrose diet (69% carbohydrate) Access: 3 h Frequency: Daily (D) Duration: ~3 weeks per experiment following one-week post-surgery recovery time. Total ~2 months. Calorie Restriction: 80% of free-feeding intake for NTX no-choice experiment only. | Male Sprague Dawley rats were implanted bilaterally with guide cannula in the PVN. The effects of the mu-opioid agonist DAMGO (0, 0.025, 0.25, and 2.5 nm, injected unilaterally to stimulate feeding) and the general opioid antagonist NTX (0, 10, 30, and 100 nmol, injected bilaterally) to inhibit feeding in consumption of fat and sucrose diets were assessed. The effect of peripheral subcutaneous injections of NTX (SQ; 0, 0.03, 0.1, and 0.3 mg/kg) was also assessed. |
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Boggiano et al., 2005 [55] | Species: Rat Binge food: Oreo cookies Access: Binge eating was produced in the R + S group through 3 cycles of restriction-refeeding, each of which lasted 12 days. Refeeding consisted of presentation of cookies for a short period, followed by ad lib chow. Frequency: 12-day cycle: 5 days ad lib chow or restriction, 2 days ad lib chow and cookies, 4 days ad lib chow, 1 day stress/no stress. Duration: 3–17 cycles of 12 days of restriction/refeeding followed by a test day on day 13. | Female Sprague Dawley rats were exposed to the binge paradigm with or without stress or restriction. The groups were as follows: Restriction and Stress (R + S), Restriction but No Stress (R + NS), Stress but No history of Restriction (NR + S), and a group with No History of Restriction or Stress (NR + NS) The effects of naloxone (1 mg/kg) and butorphanol (8 mg/kg) on binge eating were assessed. |
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Hagan & Moss, 1991 [57] | Species: Rat Binge Food: Standard chow Access: 1–4 h Frequency: Daily Duration: >1 year Calorie Restriction: Limited access to 4 h per day for first deprivation (DEP) episode, 1-to-3 h for 2nd and 3rd episodes. | Female Sprague Dawley rats were deprived for 3 episodes down to 75% normal body weight (1st episode) or 80% normal body weight (2nd and 3rd episodes) by limiting access to standard chow to 4 h per day (1st episode) or 2–3 h per day (2nd and 3rd episodes), followed by recovery to normal weight. Control group had ad libitum access. Once recovered, food was removed 40–60 min before testing. Intake of chow was measured 1, 2, and 3 h after butorphanol (SQ; 8 mg/kg) or vehicle. |
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Estrogenic | |||
Study | Methods | Details | Major Findings |
Anversa et al., 2020 [59] | Species: Mouse Binge Food: Reese’s peanut butter drops and Nestlé chocolate drops. Access: 2 h for days 5–6 of the 8-day cycle Frequency: 8-day cycle: 1–4 days of calorie restriction, 5–8 days ad libitum feeding. Day 8 was the stress. Duration: 16 days, 2 cycles Calorie Restriction: 68% of ad libitum standard chow Stress: 15 min exposure to sight and smell of binge food without the ability to consume it. (Frustration Stress) | Male and female C57BL/6J mice. A subset of female mice received ovariectomy (OVX), OVX + estrogen replacement, sham, or control (no surgery or stress). |
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Brutman et al., 2019 [62] | Species: Rat Binge Food: High-fat diet (40% fat) Access: 2 h Frequency: Every 3rd day (HFD-3D) or every day (HFD-ED) Duration: 45 days Calorie Restriction: None | Female Long Evans rats were exposed to HFD 3D, HFD-ED, or chow. Following the binge paradigm, rats were training for operant responding for sucrose pellets. A subset of rats underwent ovariectomy (OVX), or sham OVX, with or without estrogen (E2) treatment. |
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Di Bonaventura et al., 2017 [63] | Species: Rat Binge Food: Sweetened hazelnut cocoa spread (52%), ground standard rat chow (33%), and 15% water. Access: 2 h for days 5–6 of the 8-day cycle Frequency: 8-day cycle: 1–4 days of calorie restriction, 5–8 days ad libitum feeding. Duration: 24 days, day 25 test day Calorie Restriction: 66% of ad libitum standard chow Stress: 15 min exposure to sight and smell of binge food without the ability to consume it. (Frustration Stress) | Female Sprague Dawley rats were assessed by the vaginal cytology to determine ovarian phase. Additionally, rats underwent ovariectomy and received estrogen (E2) or oil (OIL) to determine the influence on binge eating. Brain region expression of phosphorylated extracellular signal-regulated kinases (pERK) were assessed. |
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Yu et al., 2011 [65] | Species: Rat Binge food: Vegetable shortening. Access: 1 h Frequency: Intermittent 3 non-consecutive days (INT) per week. Duration: 4 weeks Calorie Restriction: None | Female ovariectomized Sprague Dawley rats were assigned to 1/3 of 4-day cyclic hormone treatments: estradiol (E) benzoate, progesterone (P), both, or oil vehicle, followed by an INT binge feeding protocol. The individual roles of estradiol (E) and progesterone (P) in the control of food intake and body weight in ovariectomized rats were assessed. |
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Babbs et al., 2013 [60] | Species: Rat Binge Food: Vegetable shortening Access: 1 h in week 1, 40 min in week 2, and 20 min in weeks 3 and 4. Frequency: 3 times a week on non-consecutives days Duration: 4 weeks Calorie Restriction: None | Female Sprague Dawley rats were ovariectomized (OVX) and received 2-hydroxyestradiol (2-OHE2) or vehicle via osmotic pump. Binge eating behavior was also compared with sham OVX (Intact). Binge eating male Sprague Dawley rats were implanted with microdialysis cannula targeting the prefrontal cortex (PFC) to measure dopamine (DA) efflux-administered acute vehicle or 2-OHE2 (3 μg/kg; IP). |
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Babbs et al., 2011 [61] | Species: Rat Binge food: Vegetable shortening Access: 1 h Frequency: Daily (D) or Intermittent (INT) on non-consecutive days, 3 days a week. Duration: >5 weeks Calorie Restriction: None | Two cohorts (1 male and 1 female) of Sprague Dawley rats were exposed to a daily (D) or intermittent (INT) limited-access, binge eating paradigm for 5 weeks. Assessment of the estrogen system on binge eating behavior of 2OHE2 (1, 3, and 10 ug/kg; IP), vehicle, or 2-methoxyestradiol (2ME2; 3.0 µg/kg; IP) immediately prior to fat access following the 5-week binge-induction period. |
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Yu et al., 2008 [64] | Species: Rat Binge food: Vegetable shortening Access: 1 h Frequency: Daily (D; low restriction) or Intermittent (3 non-consecutive days; INT; high restriction) per week. Duration: 6 weeks Calorie Restriction: None | Ovariectomized female Sprague Dawley rats were exposed to a binge feeding paradigm of either chow only, INT, or D. The effect of ovarian hormones E (estradiol benzoate and P (progesterone), 2 ug/100 µL and 500 µg/100 µL sesame oil or oil vehicle, respectively, injected every 4 days) on binge feeding behavior was assessed. |
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Corticotropin-releasing factor (CRF)/Stress-Related Studies | |||
Study | Methods | Details | Major Findings |
Di Bonaventura et al., 2017 [69] | Species: Rat Binge Food: Sweetened hazelnut cocoa spread (52%), ground standard rat chow (33%), and 15% water. Access: 2 h for days 5–6 of the 8-day cycle Frequency: 8-day cycle: 1–4 days of calorie restriction, 5–8 days ad libitum feeding. Duration: 24 days, day 25 test day Calorie Restriction: 66% of ad libitum standard chow Stress: 15 min exposure to sight and smell of binge food without the ability to consume it. (Frustration Stress) | Female Sprague Dawley rats were exposed to the binge eating paradigm with CRF1 receptor antagonist R121919 (IP; 0,10. 20 mg/kg) or metyrapone (IP; 0, 50, 100 mg/kg). Non-stressed rats were treated with corticosterone (IP; 2.5 mg-15 mg/kg). In another set of rats, crhr1 mRNA was assessed in the BNST, CeA, BLA, and paraventricular nucleus. Lastly, binge eating was assesed following CeA or BLA injections of the CRF receptor antagonist D-Phe-CRF (12–41) (300 ng/side). |
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Di Bonaventura et al., 2014 [68] | Species: Rat Binge Food: Sweetened hazelnut cocoa spread (52%), ground standard rat chow (33%), and 15% water. Access: 2 h for days 5–6 of the 8-day cycle Frequency: 8-day cycle: 1–4 days of calorie restriction, 5–8 days ad libitum feeding. Duration: 24 days, day 25 test day Calorie Restriction: 66% of ad libitum standard chow Stress: 15 min exposure to sight and smell of binge food without the ability to consume it. (Frustration Stress) | Female Sprague Dawley rats were exposed to a binge eating paradigm with or without stress or restriction. The systemic effects of the CRF-1 receptor antagonist R121919 (10 or 20 mg/kg, SQ) were assessed. Intraventricular injections (ICV) or intra-BNST injection of nonselective CRF receptor antagonist D-Phe-CRF (12–41) (ICV dose 100–1000 ng; BNST dose; 10–50 ng/side) were also determined. Regional C-Fos immunoreactivity (IR) was assessed. |
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Gut peptides | |||
Study | Methods | Details | Major Findings |
Pierce-Messick and Pratt, 2020 [70] | Species: Rat Binge Food: High-fat, high-sucrose diet Access: 2 h Frequency: Daily (D) Duration: ~6 weeks Calorie Restriction: None | Male Sprague Dawley rats were implanted with bilateral cannula above the nucleus accumbens core. The effects of nucleus accumbens injections of the GLP-1 receptor agonist exendin 4 (EX4) (0, 0.05, and 0.1 µg/side) of antagonist exendin 9 (EX9) (0, 2.5, and 5.0 µg/side) on binge food consumption with and without simultaneous mu-opioid receptor stimulation (via DAMGO; 0.25 ug/side) was assessed. |
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Cornejo et al., 2019 [67] | Species: Mouse Binge Food: High palatable pellets (21.1% fat, 22.5% carbohydrates) Access: 2 h Frequency: Daily Duration: 4 consecutive days Calorie Restriction: None | Male C57BL/6J mice were investigated for growth hormone secretagogue receptor (GHSR) activity. Ghrelin (300 pmol; ICV) and LEAP2 (liver-expressed antimicrobial peptide 2; 600 pmol/g SQ; 600 pmol ICV), [D-Lys3]-GHRP-6 (2 nmol ICV), JMV2959, (3 nmol ICV), and K-(D-1-Nal)-FwLL-NH2 (1 nmol; ICV) were used to investigated GHSR in the periphery and brain. |
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Bake et al., 2017 [66] | Species: Rat and Mouse Binge Food: High-fat diet (60% Fat) Access: 2 h Frequency: Daily Duration: >2 weeks Calorie Restriction: None | Male Sprague Dawley rats were implanted with intracerebroventricular (ICV) cannulae or intra-VTA cannulae and administered acute ghrelin (1 or 2 µg/mL) prior to the binge. In a subset of rats, chronic ICV ghrelin (0.5 μg/h for 28 days) with 10 days standard chow/18 days on binge paradigm was evaluated. Another set of ghrelin receptor knockout (GHS-R KO) mice were examined for their binge phenotype. |
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Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) | |||
Study | Methods | Details | Major Findings |
Le et al., 2021 [80] | Species: Mouse Binge Food: High-fat diet Access: 1 h Frequency: Daily Duration: 5 days Calorie Restriction: None | Male and female C57BL/6/J (WT) tyrosine hydroxylase (TH-CRE) and pituitary adenylate cyclase-activating polypeptide (PACAP:CRE) mice (on a C57BL6/J background) were used. Experiments were designed to examine the ventromedial nucleus (VMN) PACAP neurons projects to the ventral tegmental area (VTA) and binge eating. Female WT mice were ovariectomized (OVX) and received vehicle or SQ estrogen daily. Immediately before binge access, WT mice were injected with PACAP1–38 (30 pmol, 0.2 μL) or 0.9% saline vehicle (0.2 μL) into the VTA. Electrophysiological recordings from TH-CRE and PACAP-CRE were taken. |
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Hurley et al., 2016 [77] | Species: Rat Binge Food: Western diet (41% Fat) Access: 15 min (meal 2; M2) Frequency: Daily Duration: 2 weeks Calorie Restriction: Daily 2 h standard chow access (meal 1; M1), 30 min before M2. | Male Sprague Dawley rats were implanted intra-ventromedial hypothalamus (VMN) and intra-nucleus accumbens (NAc) cannula. Binge eating paradigm consisted of M2 as binge food or standard chow as control. Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP; 50 pmol/side) was injected in the either intra-VMN or intra-NAc to investigate the regional PACAP influence on binge-like eating. |
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Orexin | |||
Study | Methods | Details | Major Findings |
Schuler and Koch, 2022 [87] | Species: Rat Binge Food: Vegetable fat Access: 1 h Frequency: Daily (non-binge) or Every other day (binge) Duration: 6 weeks Calorie Restriction: None | Male Lister Hooded rats were trained and screened for impulsivity on a five-choice serial reaction time task. After exposure to the binge eating paradigm, rats were bilaterally implanted with guide cannula target the NAC shell. Rats received microinfusions of either vehicle, orexin 1 receptor anatagonist (SB-338467; 500 ng/0.3 μL), or cocaine-and amphetamine-regulated transcript antibodies (CARTaB; 1:500) immediately before acess to the binge food. Microinfusions were 2–3 days apart. |
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Valdivia et al., 2015 [85] | Species: Mouse Binge Food: High-fat diet (HFD: 22.5% carbohydrate, 22.8% proteins, 21.1% fat, 23.0% fibers, 5.6% minerals, and 5.0% humidity). Access: 2 h Frequency: Daily Duration: 4 days Calorie Restriction: None | C57BL/6J mice (WT; wild type) were exposed to the 1 or 4 day of binge food, ad libitum binge food, or standard chow (no binge food). Regional immunoreactivity (IR) for tyrosine hydroxylase (TH), orexin, or c-Fos was determined. In separate experiments the influence of orexin, by injection of orexin 1 selective antagonist SB-334867 (5 mg/Kg, IP), and ghrelin, by use of growth hormone secretagogue receptor (GHSR)-null mice, were determined. |
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Piccoli et al., 2012 [83] | Species: Rat Binge food: Paste mixture of Nutella (52%), food pellets (33%), and water (15%). Access: 2 h for days 5–6 of the 8-day cycle Frequency: Three 8-day cycles: 1–4 days of calorie restriction, 5–8 days ad libitum feeding. Duration: 24 days, day 25 test day. Calorie Restriction: 4 days per week at 66% restriction of ad libitum chow. Stress: 15 min exposure to sight and smell of binge food without the ability to consume it. (Frustration Stress) | Female Sprague Dawley rats were exposed to a binge eating paradigm of restriction (R) and stress (S). Effects of GSK1059865 (a selective OX1R antagonist) (10 and 30 mg/kg; IP), JNJ-10397049 (a selective OX2R antagonist) (1, 3 mg/kg; IP), and SB-649868 (a dual OX1R/OX2R receptor antagonist) (3, 10 mg/kg; gavage) on binge eating were assessed. |
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Sigma (σ) receptors | |||
Study | Methods | Details | Major Findings |
Cifani et al., 2020 [72] | Species: Rat Binge Food: Sweetened hazelnut cocoa spread (52%), ground standard rat chow (33%), and 15% water. Access: 2 h for days 5–6 of the 8-day cycle Frequency: 8-day cycle: 1–4 days of calorie restriction, 5–8 days ad libitum feeding. Duration: 24 days, day 25 test day Calorie Restriction: 66% of ad libitum standard chow Stress: 15 min exposure to sight and smell of binge food without the ability to consume it. (Frustration Stress) | Female Sprague Dawley rats were exposed to the binge paradigm or three control conditions: No calorie restriction, No Stress, or No calorie and No Stress. A potent novel sigma1 (σ1), receptor antagonist,1,3-dioxane derivative, 9-Benzyl-3-phenyl-1,5-dioxa-9-azaspiro[5.5]undecane, was evaluated in binge eating rats. |
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Del Bello et al., 2019 [74] | Species: Rat Binge Food: Sweetened hazelnut cocoa spread (52%), ground standard rat chow (33%), and 15% water. Access: 2 h for days 5–6 of the 8-day cycle Frequency: 8-day cycle: 1–4 days of calorie restriction, 5–8 days ad libitum feeding. Duration: 24 days, day 25 test day Calorie Restriction: 66% of ad libitum standard chow Stress: 15 min exposure to sight and smell of binge food without the ability to consume it. (Frustration Stress) | Female Sprague Dawley rats were dosed with a novel σ1 receptor antagonist (1, 3, and 7 mg/Kg). Compound was the racemic spipethiane analogue (2-(1-Benzylpiperidin-4-yl)thiochroman-4-one) (±)-1. |
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Other targeting compounds | |||
Study | Methods | Details | Major Findings |
Kania et al., 2020 [79] | Species: Rat Binge Food: Sweetened hazelnut cocoa spread (52%), ground standard rat chow (33%), and 15% water. Access: 2 h for days 5–6 of the 8-day cycle Frequency: 8-day cycle: 1–4 days of calorie restriction, 5–8 days ad libitum feeding. Duration: 36 days; test day (day 37). Calorie Restriction: 66% of ad libitum standard chow Stress: 15 min exposure to sight and smell of binge food without the ability to consume it. (Frustration Stress) | Female Sprague Dawley rats were exposed to the binge paradigm or control conditions (No calorie restriction on days 1–4 of the 8-day cycle and No Stress). Relaxin-family peptide-3 receptor (RXFP3) antagonist R3(B1-22)R (1 ug/0.5 uL in ACSF, 0.5 uL bilateral) or vehiclewere injected into the hypothalamic paraventricular nucleus (PVN; magnocellular region) 15 min before access to the binge food on test day. |
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Romano et al., 2020 [84] | Species: Rat Binge Food: Sweetened hazelnut cocoa spread (52%), ground standard rat chow (33%), and 15% water. Access: 2 h for days 5–6 of the 8-day cycle Frequency: 8-day cycle: 1–4 days of calorie restriction, 5–8 days ad libitum feeding. Duration: 24 days, day 25 test day Calorie Restriction: 66% of ad libitum standard chow Stress: 15 min exposure to sight and smell of binge food without the ability to consume it. (Frustration Stress) | Female Sprague Dawley rats were exposed to the binge paradigm or three control conditions: No calorie restriction, No Stress, or No calorie and No Stress. Oleoylethanolamide (OEA) was dose-dependently administered (2.5, 5, and 10 mg/kg; IP) to suppress binge eating. OEA effects on binge eating rats were measured by neural activation, c-Fos activation, oxytocin receptor expression, and monoamine turnover. OEA effect on oxytocin on corticotropin-releasing factor (CRF) and oxytocin mRNA in hypothalamic and extrahypothalamic regions were also examined. |
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Feltmann et al., 2018 [75] | Species: Rat Binge Food: Chocolate-flavored sucrose pellets Access: 10 min Frequency: daily Duration: 48 days Calorie Restriction: 2 h prior to binge food. | Male Lister Hooded rats were exposed to a binge paradigm of negative anticipatory contrast (10 min chow/10 min binge food). After stable intake, the dose-dependent effects of a novel monoamine stabilizer OSU6162 (SQ; 5, 10, 15, and 30 mg/kg) were assessed. |
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Ferragud et al., 2017 [76] | Species: Rat Binge Food: Chocolate-flavored, high-sucrose (50% kcal) AIN-76A-based diet (5TUL: 66.7% carbohydrate, 12% fat) Access: 1 h Frequency: Daily Duration: >15 days Calorie Restriction: None | Male Wistar rats were administered a highly selective Trace Amine-Associated Receptor 1 (TAAR1) full-agonist RO5256390 (0, 1, 3, 10 mg/kg, IP) 30 min prior to binge food access. |
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Hurley et al., 2016 [78] | Species: Rat Binge Food: Western diet (41% Fat) Access: 30 min Frequency: Daily Duration: 2 weeks Calorie Restriction: None | Male Sprague Dawley rats were dosed with N-acetylcysteine (NAC) or saline by systemic (90 mg/kg IP) or intraventricular (10 μg ICV) administration. Binge food intake and saccharin (0.15%) conditioned taste aversion (CTA) were assessed. |
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Bharne et al., 2015 [71] | Species: Rat Binge Food: Hhigh-fat, sweet palatable diet (HFSPD; 40% fat as vegetable shortening, 40% protein, and 20% carbohydrate with sweetened milk) Access: 2 h Frequency: Every other day Duration: 4 weeks Calorie Restriction: None | Male Wistar rats were implanted with lateral ventricle ICV cannula and the effects of cocaine- and amphetamine-regulated transcript peptide (CART; 1, 1.5 and 2 µg/rat), CART antibody (1:500 and 1:250 dilution, 5 µL/rat), and the CB1 inverse agonist rimonabant (1, 3, and 10 mg/kg; IP) before binge food access. Morphometric analysis of CART immunoreactivity in feeding- and reward-related brain areas was investigated. |
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Freund et al., 2015 [86] | Species: Rat Binge Food: All-vegetable shortening. Access: 1 h Frequency: Intermittent on non-consecutive days, 3 days a week. Duration: 5 weeks Calorie Restriction: None | Male and female Sprague Dawley rats received the tricyclic antidepressant clomipramine (CMI, 15 mg/kg; IP; BID) or vehicle during postnatal day (P) 9–16. Spontaneous alternation task, elevated plus maze, and marble burying were performed at three developmental time points P25, P60, and P100. In a separate experiment, rats were observed for sucrose pellet consumption, which began on P60 and P100. In another experiment, rats were exposed to binge eating paradigm on P55. Rats were also classified as binge-prone based on the upper 25% of consumption of chow. |
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Di Bonaventura et al., 2013 [82] | Species: Rat Binge Food: Sweetened hazelnut cocoa spread (52%), ground standard rat chow (33%), and 15% water. Access: 2 h for days 5–6 of the 8-day cycle Frequency: 8-day cycle: 1–4 days of calorie restriction, 5–8 days ad libitum feeding. Duration: 24 days, day 25 test day Calorie Restriction: 66% of ad libitum standard chow Stress: 15 min exposure to sight and smell of binge food without the ability to consume it. (Frustration Stress) | Female Sprague Dawley rats were exposed to a binge paradigm with or without stress or restriction. The central effects of nociception/orphanin FQ (N/OFQ) on binge eating were determined by intracerebroventricular (ICV) injection of N/OFQ (0.5-1 nmol/rat) or regionally mRNA by in situ hybridization of NOP receptor and ppN/OFQ. |
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Di Bonaventura et al., 2019 [88] | Species: Rat Binge Food: Sweetened hazelnut cocoa spread (52%), ground standard rat chow (33%), and 15% water. Access: 2 h for days 5–6 of the 8-day cycle Frequency: 8-day cycle: 1–4 days of calorie restriction, 5–8 days ad libitum feeding. Duration: 24 days, day 25 test day Calorie Restriction: 66% of ad libitum standard chow Stress: 15 min exposure to sight and smell of binge food without the ability to consume it. (Frustration Stress) | Female Sprague Dawley rats received a single dose of a A2A adenosine receptor antagonist ANR 94 (1 mg/kg), agonist VT 7 (0.1 mg/kg, IP), combination (pretreatment ANR 94 followed by VT 7 15 min later, IP), or vehicle before binge food access. Binge eating intake effects werestudied on A2A adenosine receptor gene expression and DNA methylation in the amygdaloid complex. |
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Di Bonaventura et al., 2012 [81] | Species: Rat Binge food: Paste mixture of Nutella (52%), food pellets (33%), and water (15%). Access: 2 h for days 5–6 of the 8-day cycle Frequency Three 8-day cycles: 1–4 days of calorie restriction, 5–8 days ad libitum feeding. Duration: 24 days, day 25 test day. Calorie Restriction: 4 days per week at 66% restriction of ad libitum chow. Stress: 15 min exposure to sight and smell of binge food without the ability to consume it. (Frustration Stress) | Female rats were exposed to a restricting(R)/refeeding binge eating paradigm with or without stress (S). The effect of the A2A adenosine receptor (AR) agonists, CGS 21680 and VT 7 (0.1 and 0.05 mg/kg IP), on intake of highly palatable food (HPF) on sated rats, and low-palatability food (LPF) intake in food-deprived rats was assessed. |
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Cifani et al., 2010 [73] | Species: Rat Binge food: Paste mixture of Nutella (52%), food pellets (33%), and water (15%). Access: 2 h for days 5–6 of the 8-day cycle Frequency: 8-day cycle: 1–4 days of calorie restriction, 5–8 days ad libitum feeding. Duration: 24 days, day 25 test day. Calorie Restriction: 4 days per week at 66% restriction of ad libitum chow. Stress: 15 min exposure to sight and smell of binge food without the ability to consume it. (Frustration Stress) | Female Sprague Dawley rats were exposed to a model of binge eating by three 8-day cycles of food restriction/refeeding (R) and stress (S). The effect of Rhodiola rosea dry extract (3% rosavin, 3.12% salidroside) in this model of binge eating was assessed. Additionally, the bioactive constituents of rosavin and salidroside were assessed. |
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3.5.1. Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP)
3.5.2. Orexin Receptor-Targeting Compounds
3.5.3. Sigma (σ) Receptors
3.5.4. Other Targeting Compounds
3.6. Combinational or Direct Comparisons of Multiple Compounds Acting on Different Systems
3.6.1. Fluoxetine (FLX) Compared with Other Compounds
3.6.2. Lisdexamfetamine (LDX) Compared with Other Compounds
Fluoxetine Compared with Other Compounds | |||
Study | Methods | Details | Major Findings |
Fadahunsi et al., 2022 [90] | Species: Mice Binge Food: High-fat diet (58% fat) Access: 48 h (initial binge)/24 h (subsequent binges). Binge asessed after 2.5 h. Control group had binge food ad libitum. Frequency: Once a week Duration: 3 weeks Calorie Restriction: None | Male C57BL/6J mice were exposed to the binge eating paradigm To determine the influence of the serotinergic psycheldelic, psilocybin, mice received an IP injection of vehicle (saline), FLX (30 mg/kg), or psilocybin (3 mg/kg) 30 min prior to a scheduled binge. |
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Hardaway et al., 2016 [92] | Species: Mice Binge Food: High-fat diet (60% Fat) Access: 1 h Frequency: Daily Duration: >14 days Calorie Restriction: None | Male and female C57BL/6J mice were exposed to the binge eating paradigm, continuous access, or no access to the binge food. Binge food intake was assessed following nociceptin receptor antagonist (SB 612111, 0.1–10 mg/kg; IP) or FLX (30 mg/kg; IP) administration. |
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Xu et al., 2016 [94] | Species: Mice Binge Food: High-fat diet (40% kcal from fat) Access: 24 h; binge intake measured 2.5 h Frequency: Once per week Duration: >7 weeks Calorie Restriction: None | Transgenic mice were compared with wild-type (WT) mice. All were on C57 Bl/6 background. 5-Hydroxytryptamine (5HT) 2C Receptors (2C-null) mice, 2C null in dopamine (DA) neurons (DA-2C-KO), or 2C expressed only in DA neurons (DA-2C-RE). Mice were also exposed to 2C agonist, lorcaserin (6 mg/kg; IP), and other 5HT agents (FLX; 10 mg/kg; IP or d-fenfluramine; 3 mg/kg; IP). |
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Czyzyk et al., 2010 [89] | Species: Mice Binge Food: High-energy diet (Teklad 95217) Access: 48 h (initial binge)/24 h (subsequent binges). Binge asessed after 2.5 and 24 h. Control group had binge food ad libitum. Frequency: Continuous or once per week (Intermittent). Duration: ~8 weeks Calorie Restriction: None | Male C57BL/6 mice were split into 3 groups: Chow, Continuous, or Intermittent. Pharmacological evaluation of binge-like eating behavior was performed using baclofen (0.3, 1, and 3 mg/kg), topiramate (10, 30, and 100 mg/kg), and FLX (3, 10, and 30 mg/kg). |
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Cifani et al., 2009 [98] | Species: Rat Binge food: Paste mixture of Nutella (52%), food pellets (33%), and water (15%). Access: 2 h for days 5–6 and 13–14 of the 8-day cycles (second cycle). Frequency: Three 8-day cycle: 1–4 days of calorie restriction, 5–8 days ad libitum feeding. Duration: 24 days (test day 25). Calorie Restriction: 4 days per week at 66% restriction of ad libitum chow. Stress: 15 min exposure to sight and smell of binge food without the ability to consume it. (Frustration Stress) | Female Sprague Dawley rats were split into 4 groups: nonrestricted and not exposed to stress (NR + NS), restricted and not exposed to stress (R + NS), nonrestricted and exposed to stress (NR + S), and restricted and exposed to stress (R + S). Animals were exposed to the binge eating paradigm. The predictive validity of the restriction/refeeding/frustration stress model of binge eating was evaluated. The effects of FLX (3, 10 mg/kg), sibutramine (1, 3 mg/kg), topiramate (30, 60 mg/kg), and midazolam (5, 10 mg/kg) with vehicle were assessed. |
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Hagan et al., 1997 [91] | Species: Rat Binge food: Kellogg’s Froot Loops cereal (4.0 Kcal/g; 88% carbohydrate, 3% fat, 6% protein) given as palatable carbohydrate-rich food. Mars almond M&Ms (5.48 kCal/g; 57% carbohydrate, 30% fat, 8& protein) given as palatable fat-rich food. Access: 2 h Frequency: Daily (D) after injections for 2 h for each of the two experiments. Duration: 2 experiments in isolation 3 months apart; ~5 months total. Calorie Restriction: Animals were food-deprived 24 h before testing to induce feeding. | Male Sprague Dawley rats given ad libitum access to food and water. During eating tests, only the cereal and chocolate were available (no rat chow) along with water. Animals were randomly assigned to be pretreated with either SQ 1 mg/kg NAL or vehicle followed by an IP injection of one of 4 doses of FLX (0, 2.5, 5, and 10 mg/kg) with acess to binge food. Intakes were measured after 30 min and 2 h. At a 3 month time point, rats were pretreated with one of 4 doses of naloxone (NAL; 0, 0.01, 0.1, and 1 mg/kg); 10 min later, they were IP injected with 2.5 mg/kg FLX of vehicle and presented 20 min later with binge food access. |
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Lisdexamfetamine compared with other compounds | |||
Study | Methods | Details | Major Findings |
Sachdeo et al., 2019 [93] | Species: Mice Binge Food: Vegetable shortening blended with 10% sucrose Access: 30 min Frequency: 2 non- consecutive days per week Duration: 6 weeks Calorie Restriction: Two groups of mice had a 24 h calorie restriction prior to the binge period twice a week. | Female mice (C57Bl/6J background) with variant of OPRM1 gene were exposed to binge eating paradigm to determine the polymorphisms’ (A112G) influence on binge-like eating. The interactions of polymorphisms, binge eating, and lisdexamfetamine (LDX: 0.15–1.5 mg/kg: PO) and sibutramine (SIB; 0.3–3 mg/kg;PO) were also examined. |
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Hussain & Krishnamurthy, 2018 [95] | Species: Rat Binge Food: Oreo cookies Access: 2 h Frequency: Alternate days Duration: 28 days Calorie Restriction: None Stress: Rats were single housed at time of binge (Isolation stress) | Female Wister albino rats were exposed to binge or binge + stress conditions. A nootropic agent, piracetam (200 mg/kg, oral) was compared with lisdexamfetamine (LDX; 100 mg/kg, oral) for binge eating suppression in the binge + stress conditions. |
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Vickers et al., 2015 [97] | Species: Rat Binge Food: Ground chocolate (Cadbury’s Dairy Milk) Access: 2 h Frequency: Intermittent on non-consecutive days, 3 days a week. Duration: 28 days Calorie Restriction: None | Female Wistar rats were exposed to a binge eating paradigm. The dose-dependent effects of several compounds were examined; these included opioid antagonist nalmefene (0.1–1.0 mg/kg, SQ), orexin antagonist SB-334867 (3.0–30 mg/kg, IP), antipsychotic olanzapine (0.3–3.0 mg/kg, IP), GABAB agonist baclofen (1.0–10 mg/kg, IP), selective phosphodiesterase-4 inhibitor antidepressant rolipram (1.0–10 mg/kg, IP), norepinephrine and serotonin reuptake inhibitor sibutramine (0.3–5 mg/kg, PO), d-amphetamine (0.1–1.0 mg/kg, PO), and prodrug lisdexamfetamine (LDX; 0.1–1.5 mg/kg.,PO). To further investigate the effects of LDX, noradrenergic: prazosin (0.3 or 1.0 mg/kg, IP) or RX821002 (0.1 or 0.3 mg/kg, IP) or dopamine: raclopride (0.1 or 0.5 mg/kg, IP) or SCH-23390 (0.1 or 0.3 mg/kg, IP) in combination with LDX (1.0 mg/kg, PO) were considered. |
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Additional compound comparisons or combinations | |||
Study | Methods | Details | Major Findings |
Price et al., 2018 [96] | Species: Rat Binge Food: High-fat diet (45%) Access: 2 h (after a single 7-day ad libitum access period) Frequency: Once per week Duration: 5–9 weeks Calorie Restriction: None | Adult male Sprague Dawley rats were SQ administered lorcaserin (5HT-2cR agonist; 0.25, 0.5, or 1.0 mg/Kg) or pimavanserin (5HT-2aR antagonist/inverse agonist; 0.3, 1.0, or 3.0 mg/kg). Binge eating intake or binge occurrence (intake over 2 h intake during day 6 binge food ad libitium period) was assessed. |
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Corwin et al., 2016 [100] | Species: Rat Binge Food: Vegetable Shortening Access: 1 h Frequency: Intermittent on non-consecutive days or daily Duration: 5 to 8 weeks Calorie Restriction: None | Male Sprague Dawley rats were assessed for glutamate, GABA, dopamine, and opioid-related genes by qPCR 20 min before/after binge eating in PFC and VTA. Another set of rats were implanted with ventromedial (PL) or dorsomedial (M2) PFC cannula and injected with combined GABA R agonists (muscimol/baclofen), D1 R agonist (SKF 81297), D1 R antagonist (SCH 23390), D2 R agonist (quinpirole), and D2 R antagonist (eticlopride) before a scheduled binge episode. |
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Cao et al., 2014 [99] | Species: Mice Binge Food: High-fat diet (HFD; 40% fat) Access: 48 h initial exposure; 2.5 h Frequency: Once a week Duration: >2 weeks Calorie Restriction: None | Female C57BL/6 mice received bilateral ovariectomies (OVX) followed by 17β-estradiol (0.5 μg/d for 60 days; OVXE) or the containing vehicle (OVXV). Mice with tamoxifen-inducible CRE-recombinase on the tryptophan hydroxylase 2 (TPH2) promoter were used to visualize the serotonin-containing cells or to investigate the role of estrogen receptor alpha (ERα) on 5HT neurons. In addition, the roles of glucagon-like peptide (GLP-1) (4 ug/kg; SQ) as well as GLP-1 + E2 (4 ug/kg; SQ) were examined. |
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Popik et al., 2010 [102] | Species: Rat Binge food: Lard Access: 2 h Frequency: Daily Duration: 6 weeks Calorie Restriction: None | Male Sprague Dawley rats were exposed to a daily limited-access binge eating paradigm for 6 weeks. After 3 weeks, animals were given either sibutramine, memantine, or MTEP for 12 days, and their effects on binge eating behavior were assessed. In a separate experiment, rats were given ad lib access to standard chow and water for 2 weeks, followed by assignment of 1 of the 3 drugs for 7 consecutive days. Following treatment, animals were given vehicle and food consumption was measured for 5 days. |
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Pankevich et al., 2010 [101] | Species: Mice Binge Food: High-fat diet Access: Ad libitum access for 1 week (experiment 1). 1 h daily for stress experiment. Frequency: Ad libitum or daily (D) Duration: ~2 months Calorie Restriction: 75% of average caloric intake. | Male C57BL/6J mice were exposed to a model of moderate caloric restriction (CR; 10–15% weight loss), and physiological and behavioral stress measures were assessed. Changes in leptin, orexigenic hormones, melanin-concentrating hormone (MCH), and orexin levels due to stress and caloric restriction were also assessed, in addition to the effect of the MCH receptor-1 antagonist GSK-856464 (30 mg/kg; IP) and the SSRI citalopram (CIT; 20 mg/kg; IP) on binge feeding behavior. Tail suspension test on day 19 of restriction, restraint stress, and HPA axis stress response on day 21 were also performed. Chronic variable stress (CVS) was studied in a separate experiment (restraint stress). |
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Wong et al. 2009 [104] | Species: Rat Binge food: Fat/sucrose mixture (FSM) (3.2%, 10%, or 32% sucrose in vegetable shortening). Access: 1 h Frequency: Daily (D) or Intermittent (INT), 3 days/week. Duration: ~6–8 months Calorie Restriction: None | Male Sprague Daley rats were grouped according to two schedules of access, D or INT, to an optional FSM. The effects of the opioid antagonist naltrexone (0.03, 0.1, 0.3, 1 mg/kg; IP), the dopamine-2-like (D2) antagonist raclopride (0.03, 0.1, 0.3 mg/kg; IP), and the GABAA agonist baclofen (0.6, 1, 1.8, 3.2 mg/kg; IP) were assessed. |
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Will et al., 2004 [103] | Species: Rat Binge Food: High-fat diet Access: 2 h daily (D) Frequency: Daily during training, then every other day for treatment. Duration: 4–6 weeks Calorie Restriction: None | Adult male Sprague Dawley rats were implanted with bilateral guide cannulas into the nucleus accumbens core and one of the following four structures: Basolateral amygdala, central nucleus of the amygdala, posterior mediobasal amygdala, or the posterior lateral striatum. GABAA agonist, muscimol (20 ng/0.25 uL/side bilaterally), or saline were infused into the selected sites followed immediately by accumbens DAMGO (0.25 mg/0.5 uL/side bilaterally) or saline. |
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3.6.3. Additional Compound Comparisons or Combinations
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Berger, G.; Corris, J.D.; Fields, S.E.; Hao, L.; Scarpa, L.L.; Bello, N.T. Systematic Review of Binge Eating Rodent Models for Developing Novel or Repurposing Existing Pharmacotherapies. Biomolecules 2023, 13, 742. https://doi.org/10.3390/biom13050742
Berger G, Corris JD, Fields SE, Hao L, Scarpa LL, Bello NT. Systematic Review of Binge Eating Rodent Models for Developing Novel or Repurposing Existing Pharmacotherapies. Biomolecules. 2023; 13(5):742. https://doi.org/10.3390/biom13050742
Chicago/Turabian StyleBerger, Gregory, Joshua D. Corris, Spencer E. Fields, Lihong Hao, Lori L. Scarpa, and Nicholas T. Bello. 2023. "Systematic Review of Binge Eating Rodent Models for Developing Novel or Repurposing Existing Pharmacotherapies" Biomolecules 13, no. 5: 742. https://doi.org/10.3390/biom13050742